Schizophrenia after prenatal famine. Further evidence.
Schizophrenia after prenatal famine. Further evidence.
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DOI：
10.1001/archpsyc.1996.01830010027005
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发表时间：
1996
影响因子：
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通讯作者：
E. Susser;R. Neugebauer;H. Hoek;A. Brown;S. Lin;D. Labovitz;J. Gorman
中科院分区：
文献类型：
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作者：
E. Susser;R. Neugebauer;H. Hoek;A. Brown;S. Lin;D. Labovitz;J. Gorman
背景：早期的一项研究表明，产前营养缺乏是精神分裂症的决定因素，这促使我们对这一假设进行了第二次检验，使用了更精确的暴露和结果数据。方法：在1944年至1946年期间出生在荷兰西部城市的人群中，我们比较了在妊娠早期暴露于1944/1945年荷兰饥饿冬天的人群和未暴露于饥饿冬季的人群患精神分裂症的风险。从国家精神病学登记处确定了暴露和未暴露出生队列中24至48岁精神分裂症住院患者的频率。结果：在饥荒最严重时期出生的最暴露人群中，男性（RR = 1.9; 95% CI = 1.0 ~ 3.7; P = 0.05）和女性（RR = 2.2; 95% CI = 1.0 ~ 4.7; P = 0.04）患精神分裂症的风险增加了两倍，具有统计学意义（相对风险[RR] = 2.0； 95%可信区间[CI] = 1.2 ~ 3.4; P < 0.01）。在1944年至1946年的所有出生队列中，精神分裂症的风险在这一暴露队列中明显达到顶峰。结论产前营养缺乏可能与部分精神分裂症发病有关。
BACKGROUND Suggestive findings of an earlier study that prenatal nutritional deficiency was a determinant of schizophrenia prompted us to undertake a second test of the hypothesis using more precise data on both exposure and outcome. METHODS Among persons born in the cities of western Netherlands during 1944 through 1946, we compared the risk for schizophrenia in those exposed and unexposed during early gestation to the Dutch Hunger Winter of 1944/1945. The frequency of hospitalized patients with schizophrenia at age 24 to 48 years in the exposed and unexposed birth cohorts was ascertained from a national psychiatric registry. RESULTS The most exposed birth cohort, conceived at the height of the famine, showed a twofold and statistically significant increase in the risk for schizophrenia (relative risk [RR] = 2.0; 95% confidence interval [CI] = 1.2 to 3.4; P < .01) in both men (RR = 1.9; 95% CI = 1.0 to 3.7; P = .05) and women (RR = 2.2; 95% CI = 1.0 to 4.7; P = .04). Among all birth cohorts of 1944 through 1946, the risk for schizophrenia clearly peaked in this exposed cohort. CONCLUSION Prenatal nutritional deficiency may play a role in the origin of some cases of schizophrenia.