Dopamine modulation in the basal ganglia locks the gate to working memory
Dopamine modulation in the basal ganglia locks the gate to working memory
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DOI：
10.1007/s10827-005-5705-x
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发表时间：
2006-04-01
影响因子：
1.2
通讯作者：
Solla, Sara A.
中科院分区：
文献类型：
--
作者：
Gruber, Aaron J.;Dayan, Peter;Solla, Sara A.
前额叶皮层和基底神经节与工作记忆密切相关。这两种结构都受到多巴胺能神经调节的影响，对工作记忆的正常运作产生关键影响。我们提出了一个新的网络模型，以阐明相位多巴胺在这两个结构的相互作用，在启动和维持记忆活动的作用。我们认为，神经调节在保护记忆免受内部和外部噪声源的影响方面起着至关重要的作用。前额叶多巴胺释放引起的皮层增益增加有助于记忆抵御外部干扰，但不能抵御伴随反复皮层活动的内部噪音。相反，基底神经节的输出提供了门控功能，通过有针对性的皮层去抑制来增强选择记忆，从而稳定噪音和分心。基底神经节中的多巴胺通过影响纹状体中上下状态的稳定性，有效地锁住了这扇门。多巴胺参与情感加工赋予这种门控与动机显著性的特异性。我们模拟了一个空间工作记忆任务，并表明多巴胺的这些综合作用导致了上级性能。
The prefrontal cortex and basal ganglia are deeply implicated in working memory. Both structures are subject to dopaminergic neuromodulation in a way that exerts a critical influence on the proper operation of working memory. We present a novel network model to elucidate the role of phasic dopamine in the interaction of these two structures in initiating and maintaining mnemonic activity. We argue that neuromodulation plays a critical role in protecting memories against both internal and external sources of noise. Increases in cortical gain engendered by prefrontal dopamine release help make memories robust against external distraction, but do not offer protection against internal noise accompanying recurrent cortical activity. Rather, the output of the basal ganglia provides the gating function of stabilization against noise and distraction by enhancing select memories through targeted disinhibition of cortex. Dopamine in the basal ganglia effectively locks this gate by influencing the stability of up and down states in the striatum. Dopamine's involvement in affective processing endows this gating with specificity to motivational salience. We model a spatial working memory task and show that these combined effects of dopamine lead to superior performance.