The Meaning of Weaning: Influence of the Weaning Period on Behavioral Development in Mice
The Meaning of Weaning: Influence of the Weaning Period on Behavioral Development in Mice
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DOI：
10.1159/000216543
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发表时间：
2009-01-01
影响因子：
2.9
通讯作者：
Champagne, Frances A.
中科院分区：
文献类型：
--
作者：
Curley, James P.;Jordan, Emily R.;Champagne, Frances A.
产后第一周的母亲护理对啮齿类动物的后代发育具有长期影响。然而，母婴互动在该时期之后仍持续存在，在产后第 18 天至 28 天之间发生了一些生理和行为变化。在本研究中，我们调查了断奶第 21 天与第 28 天断奶对后代行为的长期影响。我们发现，如果在 PN 第 28 天断奶，雄性和雌性后代的初始社交互动水平会更高，并且探索行为也会发生性别二态性变化。较早断奶的雌性似乎也较早给自己的幼崽断奶。断奶年龄对下丘脑、杏仁核中央核和伏隔核中催产素和加压素 V1a 受体密度的水平存在性别特异性影响。这些结果表明，改变小鼠断奶年龄可能是研究神经生物学和行为中性二态性发展的有用模型。版权所有 (C) 2009 S. Karger AG，巴塞尔
Maternal care during the first week postpartum has long-term consequences for offspring development in rodents. However, mother-infant interactions continue well beyond this period, with several physiological and behavioral changes occurring between days 18 and 28 PN. In the present study, we investigate the long-term effects on offspring behavior of being weaned at day 21 PN versus day 28 PN. We found that male and female offspring engage in higher initial levels of social interaction if weaned at day 28 PN, as well as sexually dimorphic changes in exploratory behavior. Females who were themselves weaned earlier also appeared to wean their own pups earlier. Sex-specific effects of weaning age were found on levels of oxytocin and vasopressin V1a receptor density in the hypothalamus, central nucleus of the amygdala and nucleus accumbens. These results indicate that altering weaning age in mice may be a useful model for investigating the development of sexual dimorphism in neurobiology and behavior. Copyright (C) 2009 S. Karger AG, Basel