The Roles of Natural Compounds in Epigenetics
The Roles of Natural Compounds in Epigenetics
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DOI：
10.1177/1934578x1801300835
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发表时间：
2018-08
影响因子：
1.8
通讯作者：
Yanhong Yang;Zuohua Chi;R. Gao;Zili Lei
中科院分区：
文献类型：
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作者：
Yanhong Yang;Zuohua Chi;R. Gao;Zili Lei
表观遗传修饰包括DNA甲基化、组蛋白修饰、microRNA和lncRNA调控，并参与许多生理和病理过程。近年来，人们发现天然化合物在表观遗传学的调控中起着重要作用。许多天然化合物通过影响表观遗传学相关基因的表达和活性，改变mirna的表达和功能，在癌症、糖尿病、心血管疾病等多种人类疾病的预防、诊断和治疗中表现出生物和药物活性。本文综述了几种天然化合物对表观遗传学的影响及其机制，为研究天然化合物的作用提供了新的思路。
Epigenetic modifications include DNA methylation, histone modification, microRNA and lncRNA regulations, and take part in many physiological and pathological processes. Recently, it has been found that natural compounds are essential in regulation of epigenetics. By influencing the expression and activities of genes related with epigenetics and altering the expression and functions of miRNAs, many natural compounds exhibit the biological and pharmaceutical activities in the prevention, diagnosis and treatment of many kinds of human diseases, such as cancer, diabetes and cardiovascular diseases. Here in this review, the effects of several natural compounds on epigenetics and the underlying mechanisms were summarized, providing a new insight into the role of natural compounds.