Improvement of symptoms in infant colic following reduction of lactose load with lactase
Improvement of symptoms in infant colic following reduction of lactose load with lactase
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DOI：
10.1046/j.1365-277x.2001.00304.x
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发表时间：
2001-10-01
影响因子：
3.3
通讯作者：
Clayton, P
中科院分区：
文献类型：
--
作者：
Kanabar, D;Randhawa, M;Clayton, P
短暂性乳糖不耐症已被确定为婴儿绞痛的一个可能的致病因素。一项双盲随机安慰剂对照交叉研究对53名有绞痛症状的婴儿进行了调查。在饲料中添加乳糖酶后，26%的试验组（95%可信区间为12.9%至44.4%）和38%的合组（95%可信区间为18.8%至59.4%）的呼吸氢水平和总哭泣时间比安慰剂治疗至少低45%。其余的人没有同样程度的反应。这些发现表明，婴儿绞痛可能有多种病因，在相当数量的病例中，直接原因是短暂性乳糖不耐症，在这种情况下，用乳糖酶预处理饲料可产生相当大的症状益处。
Transient lactose intolerance has been identified as a possible causative factor in infant colic. A double-blind randomised placebo-controlled crossover study to investigate this has been undertaken in 53 babies with symptoms of colic. Pre-incubation of the feed with lactase resulted in breath hydrogen levels and total crying time which were both at least 45% lower than figures with placebo treatment, in 26% of the full trial group (95% confidence interval 12.9% to 44.4%), and in 38% of compliers (95% confidence interval 18.8% to 59.4%). The remainder did not respond to the same extent. These findings suggest that infant colic may have a multiple aetiology, and that in a significant number of cases the immediate cause is transient lactose intolerance, in which cases pretreatment of feeds with lactase can result in considerable symptomatic benefits.