Prospects for osteoprogenitor stem cells in fracture repair and osteoporosis.
Prospects for osteoprogenitor stem cells in fracture repair and osteoporosis.
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DOI：
10.1097/mot.0b013e328333d52c
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发表时间：
2010-02
影响因子：
2.2
通讯作者：
Clines GA
中科院分区：
文献类型：
--
作者：
Clines GA
骨再生和骨折修复是间充质干细胞侵袭、软骨形成、成骨和血管生成的复杂过程。这些主要过程的协调作用导致正常骨的重建和结构单元的恢复。然而，这些正常的骨再生机制在骨折修复失败和绝经后骨质疏松症期间崩溃。最近发现的循环多能干细胞与内皮细胞和成骨能力的混合特性引起了人们对骨折和病理性骨丢失的新的和潜在的突破性疗法的兴趣。其他间充质干细胞谱系（如脂肪细胞）和骨修复过程（如血管生成）的协同作用也可作为新的治疗靶点。最近的数据表明，已被批准用于治疗骨质疏松症的合成代谢甲状旁腺激素疗法可能会招募骨祖细胞，并在骨折修复中发挥作用。这篇综述将重点介绍干细胞和骨修复的最新信息，并探讨未来研究的潜在途径。
Bone regeneration and fracture repair is a complex process of mesenchymal stem cell invasion, chrondrogenesis, osteogenesis and angiogenesis. The coordinated actions of these principal processes results in the reconstruction of normal bone and restoration of a structural unit. However, these normal bone regenerative mechanisms breakdown during fracture repair failure and postmenopausal osteoporosis. Recent discoveries of circulating multipotent stem cells with mixed characteristics of endothelial cell and osteogenic capacity have raised interest in new and potentially breakthrough therapies for fracture and pathologic bone loss. The cooperative actions of other mesenchymal stem cell lineage such as adipocytes and processes such as angiogenesis in bone repair could also serve as novel therapeutic targets. Recent data suggests that anabolic parathyroid hormone therapy, already approved for the treatment of osteoporosis, may recruit osteoprogenitor cells and also have a role in fracture repair. This review will highlight recent information on stem cells and bone repair and examine potential avenues for future research.