Synergistic effect of immunization with a peptide cocktail inducing antibody, helper and cytotoxic T-cell responses on protection against respiratory syncytial virus.
Synergistic effect of immunization with a peptide cocktail inducing antibody, helper and cytotoxic T-cell responses on protection against respiratory syncytial virus.
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使用诱导抗体、辅助细胞和细胞毒性 T 细胞反应的肽混合物免疫对呼吸道合胞病毒的保护具有协同作用。
DOI：
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发表时间：
1999
影响因子：
3.8
通讯作者：
M. Steward
中科院分区：
文献类型：
--
作者：
S. Hsu;D. Chargelegue;O. Obeid;M. Steward
呼吸道合胞病毒(RSV)特异性细胞毒性T淋巴细胞(CTL)或中和抗体分别用合成肽免疫诱导后可保护机体免受RSV感染。在本文描述的工作中，RSV特异性中和抗体和CTL在免疫后被诱导，这些多肽由B细胞模拟表位(S1S-MAP)、T辅助表位(SH：45-60)和与融合(F)肽(F/M2：81-95)相连的CTL表位组成，与单独诱导的中和抗体和CTL表位相当。在攻击之后，在多肽鸡尾酒免疫的小鼠的肺中观察到RSV滴度降低了190倍。因此，由多肽鸡尾酒诱导的RSV特异性体液免疫和细胞免疫相结合在清除RSV方面比仅由多肽诱导的体液或细胞免疫更有效。
Respiratory syncytial virus (RSV)-specific cytotoxic T lymphocytes (CTL) or neutralizing antibodies can protect against RSV infection when induced separately by immunization with synthetic peptides. In the work described here, RSV-specific neutralizing antibodies and CTLs were induced after immunization with a cocktail of peptides consisting of a B-cell mimotope (S1S-MAP), a T-helper epitope (SH:45-60) and a CTL epitope linked to a fusion (F) peptide (F/M2:81-95) that were comparable to those induced by the peptides alone. Following challenge, a 190-fold reduction in RSV titre was observed in the lungs of peptide cocktail-immunized mice. The combination of RSV-specific humoral and cellular immunity induced by the peptide cocktail was thus more effective at clearing RSV than peptide-induced humoral or cellular immunity alone.
影响因子：
15.9
作者：
GRAHAM, BS;BUNTON, LA;KARZON, DT
通讯作者：
KARZON, DT
DOI：
10.1016/b978-0-7506-9265-6.50013-0
发表时间：
1992
期刊：
Biotechnology (Reading, Mass.)
影响因子：
--
作者：
Wertz,GW;Sullender,WM
通讯作者：
Sullender,WM