Protracted postnatal natural histories in childhood leukemia
Protracted postnatal natural histories in childhood leukemia
复制标题
DOI：
10.1002/gcc.20003
复制
发表时间：
2004-04-01
影响因子：
3.7
通讯作者：
Greaves, M
中科院分区：
文献类型：
--
作者：
Maia, AT;Koechling, J;Greaves, M
对患有一致性白血病的单卵双胞胎的研究和通过聚合酶链反应（PCR）对存档的新生儿血液的审查表明，许多儿科白血病在产前由染色体易位引发，随后在疾病诊断前经过可变的产后时期。后者被认为反映了持续的白血病前期阶段和继发性遗传事件的要求。我们试图通过检查罕见的MILL融合阳性或ETV 6/RUNX 1（TEL-AML 1）融合基因阳性急性白血病病例中的血斑来进一步研究这一点，这些病例在超过正常年龄范围的年龄被诊断出来。我们目前的证据表明，出生后的白血病前期状态的持续时间可以偶尔是非常漫长的这些生物亚型的儿童白血病，我们讨论了其生物学意义。(C)2004 Wiley-Liss，Inc.
Studies of monozygotic twins with concordant leukemia and scrutiny of archived neonatal blood by polymerase chain reaction (PCR) indicated that many pediatric leukemias are initiated prenatally by chromosomal translocation followed by a variable postnatal period before diagnosis of disease. The latter is thought to reflect a persistent preleukemic stage and a requirement for secondary genetic events. We sought to examine this further by examination of blood spots in rare cases of MILL fusion-positive or ETV6/RUNX1 (TEL-AML1) fusion gene-positive acute leukemia that were diagnosed at ages beyond the normal age range. We present evidence that the duration of the postnatal preleukemic state can occasionally be very protracted in these biological subtypes of pediatric leukemia, and we discuss its biological significance. (C) 2004 Wiley-Liss, Inc.