Diet and risk of adult glioma in eastern Nebraska, United States
Diet and risk of adult glioma in eastern Nebraska, United States
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DOI：
10.1023/a:1019527225197
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发表时间：
2002-09-01
影响因子：
2.3
通讯作者：
Heineman, EF
中科院分区：
文献类型：
--
作者：
Chen, HL;Ward, MH;Heineman, EF
目的：研究饮食与成人胶质瘤之间的潜在联系。方法：我们对内布拉斯加州东部的成人胶质瘤进行了一项以人群为基础的病例对照研究。使用从食物频率问卷中获得的信息，对236例胶质瘤患者和449例对照者的营养素和食物组摄入量进行了评估。结果：在调整潜在的混杂因素后，观察到深黄色蔬菜的摄入量与成人胶质瘤的风险呈负相关（最高四分位数与最低四分位数：OR = 0.6，p（t）rend = 0.03）和豆类（OR = 0.4，p（t）rend = 0.0003），但未观察到与预先形成的亚硝胺或高硝酸盐蔬菜的膳食来源相关。我们的营养分析揭示了成人神经胶质瘤的风险与维生素A原类胡萝卜素的饮食摄入量之间的显著负相关（最高四分位数与最低四分位数：OR = 0.5，p（t）rend = 0.005），α-胡萝卜素（OR = 0.5，p（t）rend = 0.01）、β-胡萝卜素（OR = 0.5，p（t）rend = 0.01）、膳食纤维（OR = 0.6，p（t）rend = 0.048）和豆类纤维（OR = 0.5，p（t）rend = 0.0002）。我们没有观察到显着的关联与成人神经胶质瘤的其他营养素或化合物，包括硝酸盐，亚硝酸盐，维生素C，维生素E，饱和脂肪，胆固醇，膳食纤维从谷物产品，或纤维从水果和蔬菜的摄入量的风险，结论：我们的研究不支持N-亚硝基化合物的假设，但表明类胡萝卜素和可能的其他植物化学物质在降低成人神经胶质瘤的风险的潜在作用。
Objective: To investigate potential associations between diet and adult glioma.Methods: We conducted a population-based case-control study of adult glioma in eastern Nebraska. Nutrient and food group intakes were estimated for 236 glioma cases and 449 controls using information obtained from a food-frequency questionnaire.Results: After adjusting for potential confounders, inverse associations with risk of adult glioma were observed for intakes of dark yellow vegetables (highest quartile versus lowest: OR = 0.6, p(t)rend = 0.03) and beans (OR = 0.4, p(t)rend = 0.0003), but no associations were seen for dietary sources of preformed nitrosamines or high-nitrate vegetables. Our nutrient analysis revealed significant inverse associations between risk of adult glioma and dietary intake of pro-vitamin A carotenoids (highest quartile versus lowest: OR = 0.5, p(t)rend = 0.005), alpha-carotene (OR = 0.5, p(t)rend = 0.01), beta-carotene (OR = 0.5, p(t)rend = 0.01), dietary fiber (OR = 0.6, p(t)rend = 0.048) and fiber from beans (OR = 0.5, p(t)rend = 0.0002). We observed no significant associations with risk of adult glioma for intakes of other nutrients or compounds including nitrate, nitrite, vitamin C, vitamin E, saturated fat, cholesterol, dietary fiber from grain products, or fiber from fruit and vegetables.Conclusion: Our study does not support the N-nitroso compound hypothesis, but suggests potential roles for carotenoids and possibly other phytochemicals in reducing risk of adult glioma.