The effects of ethanol and crocin on the induction of long-term potentiation in the CA1 region of rat hippocampal slices.
The effects of ethanol and crocin on the induction of long-term potentiation in the CA1 region of rat hippocampal slices.
复制标题
乙醇和藏红花素对诱导大鼠海马切片 CA1 区长时程增强的影响。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
K. Abe
中科院分区：
文献类型：
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作者：
M. Sugiura;Y. Shoyama;H. Saito;K. Abe
本实验观察了乙醇和西红花苷对大鼠海马脑片CA1区长时程增强(LTP)的影响。乙醇(50-75 mM)可抑制强直刺激(51次100赫兹)诱发的LTP。西红花苷(20微米)不影响基线突触反应，但显著阻止乙醇对LTP的抑制作用。西红花苷的这种作用是浓度依赖的(10-30微米)。西红花苷(20微米)单独作用不影响弱强直刺激(100赫兹，11个脉冲)引起的增强效应。这些体外观察表明，西红花苷直接阻止了海马体内乙醇对LTP的抑制作用。
The effects of ethanol and crocin on the induction of long-term potentiation (LTP) were investigated in the CA1 region of rat hippocampal slices in vitro. Ethanol (50-75 mM) suppressed the LTP induced by strong tetanic stimulation (51 pulses at 100 Hz). Crocin (20 microM) did not affect the baseline synaptic responses, but significantly prevented the LTP-suppressing action of ethanol. This effect of crocin was concentration dependent (10-30 microM). Crocin (20 microM) alone did not affect the potentiation induced by weak tetanic stimulation (11 pulses at 100 Hz). These in vitro observations suggest that crocin directly prevents the LTP-suppressing action of ethanol within the hippocampus.