Relation between phalangeal bone mineral density and radiographic knee osteoarthritis: a cross-sectional study.
Relation between phalangeal bone mineral density and radiographic knee osteoarthritis: a cross-sectional study.
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DOI：
10.1186/s12891-016-0918-x
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发表时间：
2016-02-11
影响因子：
2.3
通讯作者：
Lei GH
中科院分区：
文献类型：
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作者：
Deng ZH;Zeng C;Li YS;Yang T;Li H;Wei J;Lei GH
主要的报告表明，骨矿物质密度（BMD）在骨关节炎（OA）患者中较高，而其他研究并不同意。我们的目的是研究指骨BMD和影像学膝关节OA之间的横断面相关性。共有2855名参与者被纳入本研究。放射学膝关节OA定义为至少一条腿的Kelling-Lawrence（K-L）≥ 2级。使用紧凑型X线吸收测量系统（Alara MetriScan®）对非优势手的第二、第三和第四手指的中指骨进行BMD扫描。采用多变量logistic分析模型，在调整了一些潜在的混杂因素后，检验指骨BMD与放射学膝关节OA、膝关节骨赘（OST）存在和膝关节间隙狭窄（JSN）之间的关系。在95%置信区间[OR（95% CI）]下，指骨BMD中放射学膝关节OA的多变量校正比值比分别为1.08（95% CI 0.89-1.32）和0.62（95% CI 0.45-0.86）。趋势的P值为0.09。对于女性人群，影像学膝关节OA在指骨BMD上的多变量校正OR（95% CI）分别为1.01（95% CI 0.73-1.37）和0.58（95% CI 0.38 - 0.87）。趋势的P值为0.02。然而，这一阳性结果在男性亚组中不存在。骨质疏松症（OP）组OST患病率显著低于正常组（OR = 0.59，95%CI 0.40-0.88; P趋势为0.01）。骨量减少组（OR = 1.22，95%CI 1.00-1.48）和OP组（OR = 1.35，95%CI 1.00-1.84）的JSN患病率显著高于正常组。趋势的P值为0.02。该研究观察到OP患者中存在放射学膝关节OA和OST的几率低于正常受试者。骨量减少组和OP组的JSN患病率高于正常组。本文的在线版本（doi：10.1186/s12891-016-0918-x）包含补充材料，可供授权用户使用。
Major reports have suggested that bone mineral density (BMD) is higher in patients with osteoarthritis (OA), while other studies do not agree. Our aim was to examine the cross-sectional association between phalangeal BMD and radiographic knee OA. A total of 2855 participants were included in this study. Radiographic knee OA was defined as Kellgren-Lawrence (K-L) Grade ≥ 2 in at least one leg. BMD scans of the middle phalanges of the second, third and fourth digits of the nondominant hand were performed with a compact radiographic absorptiometry system (Alara MetriScan®). A multivariable logistic analysis model was applied to test the relation between phalangeal BMD with radiographic knee OA, the presence of knee osteophytes (OSTs), and knee joint space narrowing (JSN) after adjusting for a number of potential confounding factors. The multivariable-adjusted odds ratios with 95 % confidence intervals [ORs (95 % CI)] of radiographic knee OA across phalangeal BMDs were 1.08 (95 % CI 0.89–1.32) and 0.62 (95 % CI 0.45–0.86), respectively. The P for trend was 0.09. For the female population, the multivariable-adjusted ORs (95 % CI) of radiographic knee OA across phalangeal BMD were 1.01 (95 % CI 0.73–1.37) and 0.58 (95 % CI 0.38 − 0.87), respectively. The P for trend was 0.02. This positive finding, however, did not exist in the male subgroup. There was a significantly lower prevalence of OST in the osteoporosis (OP) group than in the normal group (OR = 0.59, 95 % CI 0.40–0.88; P for trend was 0.01). In contrast, the prevalence of JSN was significantly higher in the osteopenia group (OR = 1.22, 95 % CI 1.00–1.48) and the OP group (OR = 1.35, 95 % CI 1.00–1.84) than in the normal group. The P for trend was 0.02. This study observed lower odds for the presence of radiographic knee OA and OST in OP patients than in normal subjects. The prevalence of JSN was higher in the osteopenia and OP groups than in normal subjects. The online version of this article (doi:10.1186/s12891-016-0918-x) contains supplementary material, which is available to authorized users.