Flotillins in receptor tyrosine kinase signaling and cancer.
Flotillins in receptor tyrosine kinase signaling and cancer.
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DOI：
10.3390/cells3010129
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发表时间：
2014-02-19
期刊：
影响因子：
6
通讯作者：
Tikkanen R
中科院分区：
文献类型：
--
作者：
Banning A;Kurrle N;Meister M;Tikkanen R
Flotillins are highly conserved proteins that localize into specific cholesterol rich microdomains in cellular membranes. They have been shown to be associated with, for example, various signaling pathways, cell adhesion, membrane trafficking and axonal growth. Recent findings have revealed that flotillins are frequently overexpressed in various types of human cancers. We here review the suggested functions of flotillins during receptor tyrosine kinase signaling and in cancer. Although flotillins have been implicated as putative cancer therapy targets, we here show that great caution is required since flotillin ablation may result in effects that increase instead of decrease the activity of specific signaling pathways. On the other hand, as flotillin overexpression appears to be related with metastasis formation in certain cancers, we also discuss the implications of these findings for future therapy aspects.
