Wnt signaling in bone and muscle.
Wnt signaling in bone and muscle.
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DOI：
10.1016/j.bone.2015.02.009
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发表时间：
2015-11
期刊：
影响因子：
4.1
通讯作者：
Williams BO
中科院分区：
文献类型：
--
作者：
Rudnicki MA;Williams BO
Wnt信号在发育的许多方面起着关键作用。在这篇综述中，我们将简要描述Wnt配体诱导的信号通路的组成部分，然后描述目前的研究状况，因为这适用于发育和疾病方面，因为它涉及到骨骼肌和骨骼。最后，我们将讨论Wnt信号在这两种情况下的相似性和差异，以及这些途径如何（或可能）被靶向治疗肌肉骨骼疾病。
Wnt signaling plays key roles in many aspects of development. In this review, we will briefly describe the components of signaling pathways induced by Wnt ligands and then describe the current state of research as this applies to aspects of development and disease as it relates to skeletal muscle and bone. We will conclude with a discussion of the parallels and differences in Wnt signaling in these two contexts and how these pathways are being (or could potentially be) targeted for therapeutic treatment of musculoskeletal diseases.This article is part of a Special Issue entitled “Muscle Bone Interactions”.