Age-related changes in various hemopoietic progenitor cells in senescence-accelerated (SAM-P) mice.
Age-related changes in various hemopoietic progenitor cells in senescence-accelerated (SAM-P) mice.
复制标题
衰老加速（SAM-P）小鼠中各种造血祖细胞的年龄相关变化。
作者：
I. Tsuboi;K. Morimoto;T. Horie;K. Mori
本文研究了衰老过程对加速衰老（SAM-P）小鼠造血系统造血祖细胞数量的影响。老年小鼠（30-35周龄）的股骨粒细胞-巨噬细胞集落形成细胞（CFU-GM）、肥大祖细胞（肥大集落形成单位，CFU-Mast）、红系爆发形成单位（BFU-E）和红系集落形成单位（CFU-E）的数量分别下降到青年小鼠（8-12周龄）的96%、81%、83%和87%。老年小鼠股骨成纤维细胞集落形成细胞（CFU-F）数量增加到青年小鼠的315%。老年小鼠脾脏CFU-GM、CFU-Mast、BFU-E和CFU-E的数量分别为青年小鼠的7%、43%、25%和40%。相反，在骨髓中未观察到这些祖细胞的显著变化。这些结果表明，衰老过程对SAM-P小鼠造血组织的影响主要在脾脏。
The effect of aging process on the hemopoietic system in senescence-accelerated (SAM-P) mice with respect to numbers of hemopoietic progenitor cells was investigated. The numbers of femoral granulocyte-macrophage colony-forming cells (CFU-GM), mast cell progenitors (mast colony-forming units, CFU-Mast), erythroid burst-forming units (BFU-E), and erythroid colony-forming units (CFU-E) in old mice (30-35 weeks old) decreased to 96%, 81%, 83%, and 87% of those of young mice (8-12 weeks old), respectively. The numbers of femoral fibroblast colony-forming cells (CFU-F) in old mice increased to 315% of those of young mice. The numbers of splenic CFU-GM, CFU-Mast, BFU-E, and CFU-E in old mice decreased to 7%, 43%, 25%, and 40% of those of young mice, respectively. In contrast, significant changes in these progenitor cells were not observed in the bone marrow. These findings suggest that the effect of the aging process on hemopoietic tissues in SAM-P mice is predominantly in the spleen.