The Association between Dietary Lifestyles and Hepatocellular Injury in Japanese Workers
The Association between Dietary Lifestyles and Hepatocellular Injury in Japanese Workers
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DOI：
10.1620/tjem.231.257
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发表时间：
2013-12-01
影响因子：
2.2
通讯作者：
Murata, Katsuyuki
中科院分区：
文献类型：
--
作者：
Iwata, Toyoto;Arai, Kaori;Murata, Katsuyuki
血清中谷丙转氨酶（ALT）升高与非酒精性脂肪肝有关，在亚洲国家和美国经常有报道，这可能与生活方式行为有关。为了弄清特定的饮食行为是否与肝细胞损伤有关，我们对1809名年龄在19-59岁的日本汽车经销商健康保险工会男性员工的肝脏标志物和饮食生活方式（例如，不吃早餐、午餐和吃零食）进行了研究。ALT、γ -谷氨酰转移酶、天冬氨酸转氨酶（AST）与年龄、体重指数（BMI）呈正相关（P < 0.0001）。与那些很少吃方便面的人相比，在调整了可能的混杂因素（包括年龄、BMI和饮酒）后，午餐食用方便面与ALT升高（bbb30 IU/L）的比值比（ORs）在1-2次/周时为1.33(95%可信区间为1.01-1.75)，在>= 3次/周时为1.47（1.07-2.01）。同样，摄入>= 3次/周对γ -谷氨酰转移酶升高（>50 IU/L）的比值为1.42(1.02-1.99)，但对AST升高（> 30 IU/L）的比值无统计学意义。习惯性乙醇摄入与肝细胞损伤显著相关，尽管每日乙醇摄入量的阈值在肝脏标志物中存在差异。尽管OR较低，但午餐习惯性食用方便面与ALT升高有关。在日本，方便面中饱和脂肪酸的平均含量在谷类食品中是相当高的，有这种习惯的员工应避免饮食不平衡。
Elevated alanine aminotransferase (ALT) in serum, relevant to nonalcoholic fatty liver disease, has been often reported from Asian countries and the U.S., and it may be associated with lifestyle behavior. To clarify whether specific dietary behavior is associated with hepatocellular injury, we explored liver markers and dietary lifestyles (e.g., breakfast-skipping, eating for lunch, and snacking) in 1,809 male employees, aged 19-59 years, belonging to a health insurance union of automobile dealerships in Japan. ALT, gamma-glutamyltransferase, and asparate aminotransferase (AST) were positively correlated with age and body mass index (BMI) (P < 0.0001). Odds ratios (ORs) of instant noodle ingestion for lunch to ALT elevation (> 30 IU/L), after adjusting for possible confounders including age, BMI, and drinking, were 1.33 (95% confidence interval, 1.01-1.75) at 1-2 times/week and 1.47 (1.07-2.01) at >= 3 times/week, compared to those who seldom ate instant noodles. Likewise, the OR of the ingestion at >= 3 times/week to gamma-glutamyltransferase elevation (>50 IU/L) was 1.42 (1.02-1.99), but the OR to elevated AST (> 30 IU/L) was not statistically significant. Habitual ethanol intake was significantly associated with hepatocellular injury, though the threshold of daily ethanol intake differed among liver markers. Despite the low OR, habitual instant noodle ingestion for lunch is associated with ALT elevation. Since the average content of saturated fatty acids in instant noodles is considerably high among cereal foods in Japan, workers with this habit should be advised to avoid having unbalanced diets.