IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism
IP3 receptor types 2 and 3 mediate exocrine secretion underlying energy metabolism
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DOI：
10.1126/science.1114110
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发表时间：
2005-09-30
期刊：
影响因子：
56.9
通讯作者：
Mikoshiba, K
中科院分区：
文献类型：
--
作者：
Futatsugi, A;Nakamura, T;Mikoshiba, K
2型和3型肌醇1,4,5-三磷酸受体（IP3 R2和IP(3)R3）是细胞内钙释放通道，其生理作用尚不清楚。我们发现IP3 R2和IP3 R3双敲除小鼠外分泌功能障碍，导致营养物质消化困难。双突变体中唾液腺和胰腺腺泡细胞的钙信号严重受损，将分泌缺陷归因于细胞内钙释放的减少。尽管热量摄入正常，但双突变体的血糖水平较低，而且身材瘦削。这些结果表明，ip3r2和ip3r3在能量代谢和动物生长的外分泌生理学中起关键作用。
Type 2 and type 3 inositol 1,4,5-trisphosphate receptors (IP3 R2 and IP(3)R3) are intracellular calcium-release channels whose physiological roles are unknown. We show exocrine dysfunction in IP3 R2 and IP3 R3 double knock-out mice, which caused difficulties in nutrient digestion. Severely impaired calcium signaling in acinar cells of the salivary glands and the pancreas in the double mutants ascribed the secretion deficits to a tack of intracellular calcium release. Despite a normal caloric intake, the double mutants were hypoglycemic and lean. These results reveal IP3 R2 and IP3 R3 as key molecules in exocrine physiology underlying energy metabolism and animal growth.