Reference intervals for stool calprotectin in preterm neonates and their utility for the diagnosis of necrotizing enterocolitis
Reference intervals for stool calprotectin in preterm neonates and their utility for the diagnosis of necrotizing enterocolitis
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DOI：
10.1038/s41372-018-0108-9
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发表时间：
2018-10-01
影响因子：
2.9
通讯作者：
Lowe, J.
中科院分区：
文献类型：
--
作者：
MacQueen, B. C.;Christensen, R. D.;Lowe, J.
目的钙卫蛋白（Calprotectin）是一种存在于粪便中由粒细胞释放的抗菌蛋白。我们试图建立早产儿粪便钙卫蛋白参考范围，并评估是否超过上限的参考区间的水平是诊断坏死性小肠结肠炎（NEC）的研究设计粪便钙卫蛋白测量早产儿无胃肠道病理建立参考区间。为了比较，从婴儿进行“排除NEC”的评价水平绘制这些参考intervals.Results粪便钙卫蛋白参考区间，根据出生时的胎龄和校正的胎龄。水平在“排除NEC”的评价更经常高于上限的参考区间与NEC与那些没有nec.Conclusions早产儿粪便有一个更高的范围比健康足月新生儿粪便钙卫蛋白。在用粪便钙卫蛋白评估早产儿NEC时，结合校正胎龄的钙卫蛋白上限参考区间最能预测NEC的诊断。
Objective Calprotectin is an antimicrobial protein found in stool when released by granulocytes. We sought to create stool calprotectin reference ranges in preterm neonates and to evaluate whether levels exceeding the upper reference interval are diagnostic for necrotizing enterocolitis (NEC).Study design Stool calprotectin was measured in premature neonates without gastrointestinal pathology to create reference intervals. For comparison, levels from infants undergoing "rule out NEC" evaluations were plotted on these reference intervals.Results Stool calprotectin reference intervals were created according to gestational age at birth and corrected gestational age. Levels during "rule out NEC" evaluations were more often above the upper reference interval with NEC vs. those without NEC.Conclusions Stools from preterm neonates have a higher range of calprotectin than stools from healthy term neonates. In evaluating preterm neonates for NEC with stool calprotectin, a calprotectin upper reference interval that incorporates corrected gestational age best predicts the diagnosis of NEC.