Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?
Protective Role of Diabetes Mellitus on Abdominal Aortic Aneurysm Pathogenesis: Myth or Reality?
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DOI：
10.2174/1570161113666150529125127
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发表时间：
2016-01-01
影响因子：
4.5
通讯作者：
Isenovic, Esma R.
中科院分区：
文献类型：
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作者：
Radak, Djordje;Tanaskovic, Slobodan;Isenovic, Esma R.
据报道，糖尿病（DM）和腹主动脉瘤（AAA）风险之间呈负相关。除了患有DM的患者与不患有DM的患者之间AAA患病率较低之外，有数据显示DM可能对患有小AAA的患者的动脉瘤生长发挥保护作用，从而降低破裂的风险。由于动脉粥样硬化与动脉瘤具有几乎相同的风险因素，DM患者中AAA患病率降低可能表明动脉粥样硬化是一种相关特征，而不是动脉瘤的原因。或者，DM可能与影响AAA形成的因素有关。在这篇叙述性综述中，我们讨论了DM和AAA之间的负相关性。我们还评论了糖尿病，腹主动脉瘤和动脉粥样硬化的细胞和遗传病理生理机制。还考虑了DM患者常用的药物对AAA发展和生长的影响。
An inverse association between diabetes mellitus (DM) and abdominal aortic aneurysm (AAA) risk have been reported. Apart from a lower AAA prevalence among patients with vs without DM, there are data showing that DM may exert a protective role on aneurysmal growth in patients with small AAAs, thus decreasing the risk of rupture. As atherosclerosis has almost the same risk factors as aneurysms, the decreased AAA prevalence in patients with DM may indicate that atherosclerosis is an associated feature and not a cause of the aneurysms. Alternatively, DM may be associated with factors that influence AAA formation. In this narrative review, we discuss the inverse association between DM and AAA. We also comment on underlying cellular and genetic pathophysiological mechanisms of DM, AAA and atherosclerosis. The effects of drugs, commonly prescribed in DM patients, on AAA development and growth are also considered.