CD167 Acts as a Novel Costimulatory Receptor in T-Cell Activation
CD167 Acts as a Novel Costimulatory Receptor in T-Cell Activation
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CD167 在 T 细胞激活中充当新型共刺激受体
DOI：
10.1097/cji.0b013e3181acea46
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发表时间：
2009-10-01
影响因子：
3.9
通讯作者：
Yao, Libo
中科院分区：
文献类型：
--
作者：
Dang, Nana;Hu, Jinsong;Yao, Libo
最佳的T细胞活化需要抗原特异性和共刺激信号。CD 167是天然I型胶原的酪氨酸激酶受体，其生理功能包括基质稳态和细胞生长、粘附、分支和迁移，但CD 167在T细胞中的具体作用尚未被表征。在本研究中，我们发现CD 167表达的油T细胞活化后上调。CD 167与次优TCR/CD 3信号的结合诱导T细胞增殖，增强活化标志物如CD 25和CD 69的表达，提高细胞内钙动员和酪氨酸磷酸化，并引入T（H）1/Tc 1免疫应答的偏向。CD 167参与的合作也增强了对同种异体抗原的混合淋巴细胞反应。此外，CD 167在T细胞活化后迅速定位于聚集的脂筏，这为CD 167的信号机制提供了分子基础。结合这些发现，我们首次证明了CD 167可以作为T细胞活化的新型共刺激受体。
Optimal T-cell activation requires both an antigen-specific and a costimulatory signal. CD167 is a tyrosine kinase receptor for native type I collagen, its physiologic functions include matrix homeostasis and cell growth, adhesion, branching, and migration, but the specific role of CD 167 in T cells has not yet been characterized. In this study, we found that CD167 expression oil T cells was up-regulated after activation. Cooperation of CD167 engagement with suboptimal TCR/CD3 signals induced T-cell proliferation, enhanced expression of activation markers such as CD25 and CD69, elevated intracellular calcium mobilization and tyrosine phosphorylation, and introduced a bias toward a T(H)l/Tc1 immune response. Cooperation of CD167 engagement also enhanced mixed lymphocyte responses to alloantigens. Moreover, CD167 rapidly localized to the aggregated lipid rafts upon T-cell activation, this provided a molecular base for the Signaling machinery of CD167. Together these findings, we demonstrate For the first time that CD167 Could serve as a novel costimulatory receptor for T-cell activation.