The roles of integrin avb6 in cancer
The roles of integrin avb6 in cancer
复制标题
整合素 avb6 在癌症中的作用
作者：
jun NIU;ZeQun Li
整合素是在大多数细胞中表达的异源二聚体细胞表面受体家族，其中它们介导细胞-细胞和细胞-细胞外基质（ECM）相互作用。整合素avb 6是一种含有avb 6和avb 6亚基的异源二聚体。它是上皮特异性的，在伤口愈合、炎症和癌变过程中被强烈诱导。整合素avb 6被认为是一种预后指标，因为它在各种类型的癌症中上调，并且整合素avb 6表达与患者的生存时间相关。大量证据表明，整合素avb 6在肿瘤进展中具有重要意义，因为整合素avb 6已被证明调节肿瘤细胞的许多恶性行为。许多经典的致癌信号通路参与整合素avb 6介导的肿瘤进展。整合素avb 6的表达特点及其在肿瘤发生发展中的重要作用，使得以整合素avb 6为靶点的肿瘤显像和肿瘤治疗成为研究热点，从而使整合素avb 6成为一个有希望的临床检测和治疗靶点。本文综述了整合素avb 6在肿瘤中的作用及其机制。此外，还讨论了独立研究之间的共同联系和差异。© 2017爱思唯尔B. V.版权所有
Integrins are a family of heterodimeric cell surface receptors that are expressed in most cells, where they.mediate cell-cell and cell-extracellular matrix (ECM) interactions. Integrin avb6 is a heterodimer with av.and b6 subunits. It is epithelial-specific and strongly induced during wound healing, inflammation and.carcinogenesis. Integrin avb6 is considered to be a prognostic indicator because it is up-regulated in.various types of cancers and integrin avb6 expression correlates with the survival time of patients. A.large body of evidence suggests that integrin avb6 is of great significance in tumor progression, as.integrin avb6 has been demonstrated to modulate numerous malignant behaviors of tumor cells. A.number of classic oncogenic signaling pathways are involved in integrin avb6-mediated tumor progression..The expression characteristics and vital effects of integrin avb6 in the progression of tumors has.led studies to focus on integrin avb6-targeted tumor imaging and tumor therapy, which have subsequently.made integrin avb6 a promising target for clinical examination and treatment. This review.provides an overview of the current understanding of the roles and underlying mechanisms of integrin.avb6 in tumors. Furthermore, the common links as well as discrepancies between independent studies.are also discussed..© 2017 Elsevier B.V. All rights reserved.