SETTING LIMITS ON HOMEOTIC GENE-FUNCTION - RESTRAINT OF SEX-COMBS-REDUCED ACTIVITY BY TEASHIRT AND OTHER HOMEOTIC GENES
SETTING LIMITS ON HOMEOTIC GENE-FUNCTION - RESTRAINT OF SEX-COMBS-REDUCED ACTIVITY BY TEASHIRT AND OTHER HOMEOTIC GENES
复制标题
DOI：
10.1002/j.1460-2075.1994.tb06362.x
复制
发表时间：
1994-03-01
期刊：
影响因子：
11.4
通讯作者：
SCOTT, MP
中科院分区：
文献类型：
--
作者：
ANDREW, DJ;HORNER, MA;SCOTT, MP
HOM或HOX复合体的每一个同源异型基因在沿前后轴的有限结构域中沿着表达。每一种同源异型蛋白都指导着特征结构的形成，如翅膀或肋骨。在果蝇中，当热休克诱导的同源异型基因被用来在胚胎的所有细胞中产生同源异型蛋白时，只有一些细胞通过改变它们的命运来做出反应。我们已经确定了限制同源异型基因性梳减少（Scr）可以影响果蝇胚胎细胞命运的基因。在腹部角质层中，Scr被三个双胸复合体（BX-C）同源异型基因阻止诱导前胸结构。然而，两个BX-C同源异型基因，超双胸（Ubx）和abdominal-A（abd-A），对Scr指导唾液腺形成的能力没有影响。相反，Scr对唾液腺的诱导在躯干中受到同源异型基因teashirt（tsh）的限制，在最后一个腹部节段中受到第三个BX-C基因Abdominal-B（AbdB）的限制。因此，同源异型基因活性的空间限制在不同组织之间是不同的，并且是由同源异型基因转录的调节和同源异型蛋白可以发挥功能的限制引起的。
Each of the homeotic genes of the HOM or HOX complexes is expressed in a limited domain along the anterior-posterior axis. Each homeotic protein directs the formation of characteristic structures, such as wings or ribs. In flies, when a heat shock-inducible homeotic gene is used to produce a homeotic protein in all cells of the embryo, only some cells respond by altering their fates. We have identified genes that limit where the homeotic gene Sex combs reduced (Scr) can affect cell fates in the Drosophila embryo. In the abdominal cuticle Scr is prevented from inducing prothoracic structures by the three bithorax complex (BX-C) homeotic genes. However, two of the BX-C homeotic genes, Ultrabithorax (Ubx) and abdominal-A (abd-A), have no effect on the ability of Scr to direct the formation of salivary glands. Instead, salivary gland induction by Scr is limited in the trunk by the homeotic gene teashirt (tsh) and in the last abdominal segment by the third BX-C gene, Abdominal-B (AbdB). Therefore, spatial restrictions on homeotic gene activity differ between tissues and result both from the regulation of homeotic gene transcription and from restraints on where homeotic proteins can function.