Telomere length in different histologic types of ovarian carcinoma with emphasis on clear cell carcinoma.
Telomere length in different histologic types of ovarian carcinoma with emphasis on clear cell carcinoma.
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DOI：
10.1038/modpathol.2011.67
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发表时间：
2011-08
期刊：
影响因子：
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通讯作者：
Shih IeM
中科院分区：
文献类型：
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作者：
Kuhn E;Meeker AK;Visvanathan K;Gross AL;Wang TL;Kurman RJ;Shih IeM
卵巢癌是一组异质性肿瘤，具有不同的临床病理和分子特征。端粒酶活性的改变在卵巢肿瘤中已有报道，但在其特定的组织学亚型中端粒长度的模式尚未报道。在这项研究中，我们进行了定量端粒荧光原位杂交共219卵巢癌，包括106高级别浆液性癌，26低级别浆液性癌，56透明细胞癌和31低级别浆液性癌。计算癌细胞与间质细胞的平均相对端粒长度作为端粒指数。透明细胞癌的这一指数明显高于其他组织学类型（P= 0.007）。总体而言，端粒指数与死亡率之间没有关联，但当按组织学类型分层时，与端粒指数≤1的女性相比，端粒指数>1的透明细胞癌女性的死亡风险比显著增加，为4.93（95%CI 1.64-14.86，P= 0.005）。总之，我们的研究结果提供了新的证据，端粒长度显着不同的组织学类型的卵巢癌。具体而言，与其他组织学类型相比，透明细胞癌具有较长的平均相对端粒长度，并且透明细胞癌中较长的端粒与死亡率增加相关，这表明端粒长度的畸变可能在这种肿瘤的发展和进展中起重要作用。
Ovarian carcinoma is composed of a heterogeneous group of tumors with distinct clinico-pathological and molecular features. Alteration of telomerase activity has been reported in ovarian tumors but the pattern of telomere length in their specific histological subtypes has not been reported. In this study, we performed quantitative telomere fluorescence in situ hybridization on a total of 219 ovarian carcinomas including 106 high-grade serous carcinomas, 26 low-grade serous carcinomas, 56 clear cell carcinomas and 31 low-grade endometrioid carcinomas. The mean relative telomere length of carcinoma to stromal cells was calculated as a telomere index. This index was significantly higher in clear cell carcinoma compared with the other histologic types (P= 0.007). Overall there was no association between the telomere index and mortality, but when stratified by histologic types, the hazard ratio for death among women with clear cell carcinoma with a telomere index >1 was significantly increased at 4.93 (95% CI 1.64–14.86, P= 0.005) when compared with those with a telomere index ≤1. In conclusion, our results provide new evidence that telomere length significantly differs by histologic type in ovarian carcinoma. Specifically, clear cell carcinomas have longer mean relative telomere lengths compared with the other histologic types and longer telomeres in clear cell carcinoma are associated with increased mortality suggesting that aberrations in telomere length may have an important role in the development and progression of this neoplasm.