An α-Formylglycine Building Block For Fmoc-Based Solid-Phase Peptide Synthesis
An α-Formylglycine Building Block For Fmoc-Based Solid-Phase Peptide Synthesis
复制标题
用于基于 Fmoc 的固相肽合成的 α-甲酰甘氨酸结构单元
DOI：
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
C. Bertozzi
中科院分区：
文献类型：
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作者：
J. Rush;C. Bertozzi
几乎所有已知的硫酸酯酶都有一个共同的活性位点修饰，这是其活性所必需的：半胱氨酸的 转化为α-甲酰甘氨酸。我们报道了一种适合于基于Fmoc的固相肽合成的α-甲酰甘氨酸构建块的合成。将该构建块并入从结核分枝杆菌硫酸酯酶活性部位提取的合成肽中。
Nearly all known sulfatases share a common active site modification that is required for their activity: conversion of cysteine to α-formylglycine. We report the synthesis of an α-formylglycine building block suitable for Fmoc-based solid-phase peptide synthesis. The building block was incorporated into a synthetic peptide derived from the active site of a Mycobacterium tuberculosis sulfatase.