Wnt/β-catenin signaling: Structure, assembly and endocytosis of the signalosome.
Wnt/β-catenin signaling: Structure, assembly and endocytosis of the signalosome.
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Wnt/β-catenin signaling：Structure，assembly and endocytosis of the signalosome.
DOI：
10.1111/dgd.12718
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Koo BK
中科院分区：
文献类型：
--
作者：
Colozza G;Koo BK
Wnt/β-catenin信号传导是一种古老的途径，调节胚胎发育，细胞分化，增殖和成体干细胞稳态的关键方面。来自不同实验室的工作揭示了Wnt途径的分子机制，包括配体-受体相互作用的结构细节。从多项研究中出现的一个关键方面是受体复合物的内吞作用在微调Wnt/β-catenin信号传导中起着至关重要的作用。内吞作用是参与Wnt信号传导的激活和衰减的关键过程，但其如何调节仍然知之甚少。重要的是，最近的研究结果表明，Wnt还调节中枢代谢途径，例如通过肌动蛋白驱动的内吞机制获得营养物质。在这篇综述中，我们提出，Wnt途径显示出不同的特点，超越了基因表达的调控，通过连接与内吞机制。在这篇综述中，我们分析的作用，内吞作用在调节Wnt信号。我们还讨论了Wnt如何通过内吞机制调节代谢过程的最新研究结果。
Wnt/β‐catenin signaling is an ancient pathway that regulates key aspects of embryonic development, cell differentiation, proliferation, and adult stem cell homeostasis. Work from different laboratories has shed light on the molecular mechanisms underlying the Wnt pathway, including structural details of ligand–receptor interactions. One key aspect that has emerged from multiple studies is that endocytosis of the receptor complex plays a crucial role in fine‐tuning Wnt/β‐catenin signaling. Endocytosis is a key process involved in both activation as well as attenuation of Wnt signaling, but how this is regulated is still poorly understood. Importantly, recent findings show that Wnt also regulates central metabolic pathways such as the acquisition of nutrients through actin‐driven endocytic mechanisms. In this review, we propose that the Wnt pathway displays diverse characteristics that go beyond the regulation of gene expression, through a connection with the endocytic machinery. In this review, we analyze the role that endocytosis plays in regulating Wnt signaling. We also discuss recent findings on how Wnt regulates metabolic processes, through endocytic mechanisms.
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