Bone Turnover Markers in Patients with Type 2 Diabetes and Their Correlation with Glycosylated Haemoglobin Levels
Bone Turnover Markers in Patients with Type 2 Diabetes and Their Correlation with Glycosylated Haemoglobin Levels
复制标题
2 型糖尿病患者的骨转换标志物及其与糖化血红蛋白水平的相关性
DOI：
10.1177/147323000803600629
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发表时间：
2008
影响因子：
1.6
通讯作者：
Z. Umudum
中科院分区：
文献类型：
--
作者：
I. Çapoglu;A. Ozkan;B. Ozkan;Z. Umudum
这项前瞻性纵向研究的目的是在12个月的时间内调查代谢控制对2型糖尿病患者骨转换标志物的影响。该研究包括17名男性和18名女性2型糖尿病患者，年龄为37 - 66岁。平均随访时间为12 ± 1.2个月。研究开始时平均糖化血红蛋白（HbA 1C）水平为10.6% ± 1.6%，研究结束时降至7.7% ± 1.0%。研究开始时，骨吸收标志物尿脱氧吡啶啉和N-端肽的水平分别为28.6 ± 11.6 nmol/mmol肌酐和93.6 ± 13.7 nmol骨胶原当量[BCE]/mmol肌酐，并分别显著降低至17.9 ± 7.1 nmol/mmol肌酐和67.8 ± 12.8 nmol BCE/mmol肌酐，在研究结束时。在研究期间，骨形成参数也与HbA 1c水平平行显著降低。结论：2型糖尿病患者代谢紊乱的有效管理对骨转换的改善起着重要的作用。
The aim of this prospective, longitudinal study was to investigate, over a period of 12 months, the effects of metabolic control on bone turnover markers in patients with type 2 diabetes mellitus. The study included 17 male and 18 female patients with type 2 diabetes, aged 37 − 66 years. Mean follow-up period was 12 ± 1.2 months. Mean glycosylated haemoglobin (HbA1C) levels were 10.6% ± 1.6% at the start of the study and decreased to 7.7% ± 1.0% by the end of the study. Levels of the bone resorption markers, urinary deoxypyridinoline and N-telopeptide, were 28.6 ± 11.6 nmol/mmol creatinine and 93.6 ± 13.7 nmol bone collagen equivalents [BCE]/mmol creatinine, respectively, at the start of the study, and decreased significantly to 17.9 ± 7.1 nmol/mmol creatinine and 67.8 ± 12.8 nmol BCE/mmol creatinine, respectively, by the end of the study. Bone formation parameters also significantly decreased in parallel with HbA1c levels over the study period. It is concluded that effective management of metabolic disorder in patients with type 2 diabetes plays an important contribution to bone turnover improvement.