The safety and efficacy of the oral rabies vaccine SAG2 in Indian stray dogs
The safety and efficacy of the oral rabies vaccine SAG2 in Indian stray dogs
复制标题
DOI：
10.1016/j.vaccine.2006.12.054
复制
发表时间：
2007-04-30
期刊：
影响因子：
5.5
通讯作者：
Barrat, J.
中科院分区：
文献类型：
--
作者：
Cliquet, F.;Gurbuxani, J. P.;Barrat, J.
印度是世界上人类狂犬病发病率最高的国家之一。狗是狂犬病传播的主要原因。其中，流浪狗在那个国家扮演着重要角色。非肠道疫苗接种方案不足以消除狂犬病，部分原因是由于流浪狗的比例很高，很难在狗群中建立令人满意的免疫覆盖率。口服疫苗可增加犬只的免疫覆盖率，是肠外免疫的有益补充。对圈养的印度流浪狗进行了Rabidog(R)SAG2毒饵的安全性、免疫原性和有效性评估。SAG2的安全性表现为21只接种疫苗的狗没有不良的临床症状，唾液分泌，即使在免疫抑制的情况下，疫苗毒株也没有在大脑和唾液腺中复制。在攻击后109天，接种了一种高毒力的街头狂犬病病毒，杀死了所有5只对照狗，但所有9只接种疫苗的狗都存活了下来，尽管9只狗中只有5只在攻击前血清转换。(C)2007爱思唯尔有限公司。保留所有权利。
India is one of the countries with the highest prevalence of human rabies throughout the world. Dogs are primarily responsible for rabies transmission. Among them, stray dogs play a major role in that country. Parenteral vaccination programmes are insufficient to eliminate rabies partly due to difficulties in establishing satisfactory immunisation coverage in the dog population in view of the high proportion of stray dogs. Oral vaccination may be a useful adjunct to parenteral vaccination by increasing dog vaccination coverage.Safety, immunogenicity and efficacy of Rabidog (R) SAG2 bait were evaluated in Indian stray dogs in captivity. Safety of SAG2 was demonstrated by the absence of adverse clinical sign, salivary excretion and absence of replication of the vaccine strain in brain and salivary glands of 21 vaccinated dogs, even when immunodepressed.Efficacy was shown 109 days post-vaccination after challenge with a highly virulent street rabies virus which killed all five controls whereas all nine vaccinated dogs survived, despite the fact that only five out of nine had seroconverted before challenge. (c) 2007 Elsevier Ltd. All rights reserved.