Third-trimester maternal glucose levels from diurnal profiles in nondiabetic pregnancies - Correlation with sonographic parameters of fetal growth
Third-trimester maternal glucose levels from diurnal profiles in nondiabetic pregnancies - Correlation with sonographic parameters of fetal growth
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DOI：
10.2337/diacare.24.8.1319
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发表时间：
2001-08-01
期刊：
影响因子：
16.2
通讯作者：
Mello, G
中科院分区：
文献类型：
--
作者：
Parretti, E;Mecacci, F;Mello, G
目的-评估24小时血糖水平在一组非糖尿病，非肥胖孕妇，并验证母体血糖水平和胎儿生长的超声参数之间的相关性的存在。研究设计和方法-共有66名白人非肥胖孕妇与正常葡萄糖激发试验（GCT）参加了这项研究，从这个人口，我们选择了51名分娩足月（37 - 42周）活产婴儿的妇女，无先天性畸形的证据。这些妇女被要求吃三餐，并在28-38周前每两周进行一次每日血糖分析，而不改变她们的生活方式或遵循任何饮食限制。所有受试者都被教导如何使用反射仪监测他们的血糖。根据标准方法，在妊娠22、28、32和36周时通过超声扫描评估胎儿生物统计学。结果：妊娠晚期的总体每日平均血糖水平为74.7 +/- 5.2 mg/dl。妊娠28周（71.9 +/- 5.7 mg/dl）至38周（78.3 +/- 5.4 mg/dl）之间的每日平均葡萄糖值增加。我们发现，在28周之间的I-h餐后血糖值和胎儿腹围（AC）显着正相关。在32周时，我们记录了胎儿AC和母亲早餐后1小时，午餐后1和2小时，晚餐后1和2小时的血糖水平之间的正相关性，在36周时，胎儿AC和1-和2-h餐后血糖水平之间的正相关性。此外，有一个负相关性之间的头腹围比和1小时餐后血糖values.CONCLUSIONS -这项纵向研究首先提供了一个对非糖尿病，非肥胖的孕妇normoblasts的定义的贡献此外，它揭示了显着的相关性餐后血糖水平与胰岛素敏感的胎儿组织的生长，特别是，餐后1小时血糖值和胎儿AC之间的关系。
OBJECTIVE - To assess the 24-h glucose levels in a group of nondiabetic, nonobese pregnant women and to verify the presence of correlations between maternal glucose levels and sonographic parameters of fetal growth.RESEARCH DESIGN AND METHODS - A total of 66 Caucasian nonobese pregnant women with normal glucose challenge tests (GCT) enrolled in the study from this population, we selected 51 women who delivered term (from 37 to 42 weeks completed) live-born infants without evidence of congenital malformations. The women were requested to have three main meals and to perform daily glucose profiles fortnightly front 28-38 weeks without modifying their lifestyle or following any dietary restriction. All subjects were taught how to monitor their blood glucose by using a reflectance meter. Fetal biometry was evaluated by ultrasound scan according to standard methodology at 22, 28, 32, and 36 weeks of pregnancy.RESULTS - The overall daily mean glucose level during the third trimester was 74.7 +/- 5.2 mg/dl. Daily mean glucose values increased between 28 (71.9 +/- 5.7 mg/dl) and 38 (78.3 +/- 5.4 mg/dl) weeks of pregnancy. We found significant positive correlation at 28 weeks between I-h postprandial glucose values and fetal abdominal circumference (AC). At 32 weeks, we documented positive correlations between fetal AC and maternal blood glucose levels 1 h after breakfast, 1 and 2 h after lunch, and 1 and 2 h after dinner, At 36 weeks, there was a positive correlation between fetal AC and 1- and 2-h postprandial blood glucose levels. In addition, there was a negative correlation between head-abdominal circumference ratio and 1-h postprandial blood glucose values.CONCLUSIONS - This longitudinal study first provides a contribution toward the definition of normoglycemia in nondiabetic, nonobese pregnant women moreover, it reveals significant correlations of postprandial blood glucose levels with the growth of insulin-sensitive fetal tissues and, in particular, between 1-h postprandial blood glucose values and fetal AC.