Change and correlates of change in high and low density lipoprotein cholesterol after six years: a prospective study.
Change and correlates of change in high and low density lipoprotein cholesterol after six years: a prospective study.
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六年后高密度脂蛋白胆固醇和低密度脂蛋白胆固醇变化及其相关性：一项前瞻性研究。
DOI：
10.1093/oxfordjournals.aje.a113616
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发表时间：
1983
影响因子：
5
通讯作者：
Turner,JD
中科院分区：
文献类型：
--
作者：
Criqui,MH;Frankville,DD;Barrett-Connor,E;Klauber,MR;Holdbrook,MJ;Turner,JD
Criqul， M. H.（加州大学社区和家庭医学系，圣地亚哥，La Jolla, CA 92093）， D. D. Frankville， E. Barrett-Connor， M. R. Kiauber， M. J. Holdbrook和J. D. Turner。六年后高、低密度脂蛋白胆固醇变化及其相关因素：一项前瞻性研究。[J]流行病学杂志1983；118: 52-9。在Rancho Bernardo， CA， 1972-1980的一项基于人群的前瞻性研究中，研究了高、低密度脂蛋白胆固醇（HDL和LDL）的变化及其相关因素。基线和随访检查平均6年后HDL和LDL的相关性为0.72和0.68,86%的HDL和89%的LDL值在原始值的±30%以内。通过多变量分析预测HDL和LDL的变化。回归均值是脂蛋白变化最强的单一预测因子，比行为改变更重要。在行为变量中，HDL的变化与两性酒精使用的变化和女性绝经后雌激素使用的变化呈正相关，与男性肥胖指数的变化呈负相关。LDL变化与两性肥胖指数变化呈正相关。在该分析中，报告的吸烟或运动的变化与HDL和LDL的变化无关。基线和随访时脂蛋白值的相似性表明单次HDL或LDL测量具有合理的可靠性和预后有效性。多变量分析结果一般证实了目前关于脂蛋白行为相关性的横断面衍生概念。然而，回归均值的程度表明重复测量是明智的，特别是对于具有极端值的人。
Criqul, M. H. (Dept. of Community and Family Medicine, U. of California, San Diego, La Jolla, CA 92093), D. D. Frankville, E. Barrett-Connor, M. R. Kiauber, M. J. Holdbrook and J. D. Turner. Change and correlates of change in high and low density lipoproteln cholesterol after six years: a prospective study.Am J Epidemiol1983; 118: 52–9.Change and correlates of change in high and low density lipoprotein cholesterol (HDL and LDL) were studied in a prospective population-based study of 614 men and women in Rancho Bernardo, CA, 1972–1980. Correlations between baseline and follow-up examination an average of six years later were 0.72 for HDL and 0.68 for LDL, and 86% of HDL and 89% of LDL values were within ±30% of their original values. Predictions of HDL and LDL change were determined by multivariate analysis. Regression to the mean was the strongest single predictor of lipoproteln change and was more Important than behavioral change. Among the behavioral variables, HDL change was positively associated with change in alcohol use in both sexes and with change in postmeno-pausal estrogen use in women and was inversely associated with change in obesity index in men. LDL change correlated positively with change in obesity Index in both sexes. Change in reported cigarette use or exercise was unrelated to changes In HDL and LDL in this analysis. The similarity of lipoprotein values at baseline and follow-up suggests reasonable reliability and prognostic validity for a single HDL or LDL measurement. The muttivariate analysis results generally confirm current cross-sectionally derived concepts about behavioral correlates of llpoproteins. However, the degree of regression to the mean indicates the wisdom of repeat measurements, particularly for persons with extreme values.