Regulation of gene expression by reiterative transcription.
Regulation of gene expression by reiterative transcription.
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通过重复转录调节基因表达。
DOI：
10.1016/j.mib.2011.01.012
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发表时间：
2011
影响因子：
5.4
通讯作者：
TurnboughJr,CharlesL
中科院分区：
文献类型：
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作者：
TurnboughJr,CharlesL
基因调控涉及许多不同类型的转录控制机制，包括基于重复转录的机制，在重复转录中，由于上游转录物滑移，核苷酸被重复添加到新生转录物的3 '端。在这些机制中，重复转录通常由RNA聚合酶与其核苷三磷酸底物之间的相互作用调节，而不需要调节蛋白的参与。本文综述了涉及重复转录的基因调控的现状。它着重于方法，其中反复转录是控制和强调不同命运的转录本产生这种反应。回顾还包括可能的新的和根本不同的机制的基因调控依赖于条件重复转录的讨论。
Gene regulation involves many different types of transcription control mechanisms, including mechanisms based on reiterative transcription in which nucleotides are repetitively added to the 3′ end of a nascent transcript due to upstream transcript slippage. In these mechanisms, reiterative transcription is typically modulated by interactions between RNA polymerase and its nucleoside triphosphate substrates without the involvement of regulatory proteins. This review describes the current state of knowledge of gene regulation involving reiterative transcription. It focuses on the methods by which reiterative transcription is controlled and emphasizes the different fates of transcripts produced by this reaction. The review also includes a discussion of possible new and fundamentally different mechanisms of gene regulation that rely on conditional reiterative transcription.