Periodontal Disease and Chronic Kidney Disease: the Impact of Oral Health on Inflammation and Nutrition in Patients Undergoing Hemodialysis
Periodontal Disease and Chronic Kidney Disease: the Impact of Oral Health on Inflammation and Nutrition in Patients Undergoing Hemodialysis
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DOI：
10.1007/s40496-022-00313-0
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发表时间：
2022-05
影响因子：
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通讯作者：
K. Mizutani;Risako Mikami;Natsumi Saito;Eri Sakaniwa;T. Iwata
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文献类型：
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作者：
K. Mizutani;Risako Mikami;Natsumi Saito;Eri Sakaniwa;T. Iwata
综述的目的许多临床研究报道了牙周病和慢性肾脏病（CKD）之间的联系。基础研究支持炎症可能介导CKD与牙周病的关系。临床证据表明，牙周治疗可以改善肾功能。口腔健康状况不佳也被报道为接受血液透析的患者死亡率的预测因子。SummaryAlthough临床数据已证明牙周组织炎症与CKD之间存在显著相关性，但需要精心设计的研究才能达成广泛共识。在接受血液透析的患者中，营养不良和全身慢性炎症通常相互关联。牙周病可能会导致慢性炎症，并且在接受血液透析的患者中，低数量的牙齿可能与营养摄入受损有关。除了细菌感染和炎症等传统因素外，还需要对营养不良的新观点来管理CKD患者的口腔健康，特别是那些接受透析的患者。
Purpose of ReviewMany clinical studies have reported an association between periodontal disease and chronic kidney disease (CKD). This review aims to update the underlying mechanism and the findings of clinical studies.Recent FindingsBasic research supports that inflammation might mediate the association between CKD and periodontal disease. Clinical evidence suggests that periodontal treatment improves renal function. Poor oral health has also been reported as a predictor of mortality in patients undergoing hemodialysis.SummaryAlthough clinical data have demonstrated a significant association between inflammation in the periodontal tissue and CKD, well-designed studies are needed for a consensus to be widely adopted. Malnutrition and systemic chronic inflammation are often interrelated in patients undergoing hemodialysis. Periodontal disease may contribute to chronic inflammation, and it is possible that a low number of teeth may be involved in impaired nutritional intake in patients undergoing hemodialysis. A novel perspective on malnutrition might be needed to manage oral health in patients with CKD, especially those undergoing dialysis, in addition to conventional factors such as bacterial infection and inflammation.