SIZE AND MECHANICAL-PROPERTIES OF THE PHARYNX IN HEALTHY-MEN AND WOMEN
SIZE AND MECHANICAL-PROPERTIES OF THE PHARYNX IN HEALTHY-MEN AND WOMEN
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DOI：
10.1164/ajrccm/146.6.1394
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发表时间：
1992-12-01
期刊：
影响因子：
--
通讯作者：
STROHL, KP
中科院分区：
文献类型：
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作者：
BROOKS, LJ;STROHL, KP
阻塞性睡眠呼吸暂停（OSA）有一个显着的男性优势。为了确定男性和女性咽部的机械特性是否存在差异，这可能导致疾病发病率的性别差异，我们使用声脉冲技术测量了77名正常男性和98名正常女性安静呼吸时的咽部横截面积。还进行了标准肺功能检查。本文对23名男性和34名女性的咽力学进行了研究，测量了缓慢肺活量动作时咽面积的变化。性别被认为是影响咽部大小的最重要的独立因素。男性的咽部明显大于女性（3.63 +/- 0.10 vs 3.20 +/- 0.09 cm 2，平均值+/- SEM; p < 0.01）。男性和女性之间的咽力学也不同。随着肺容量的变化，男性咽部面积的变化大于女性（0.60 +/- 0.14 vs 0.12 +/- 0.12 cm 2，平均值+/- SEM; p < 0.02）。这种差异持续存在，即使在标准化的咽部大小的数据。我们发现咽部的大小和机械特性存在性别相关差异，并推测男性较大的咽部可能会被咽部大小随肺体积变化而发生的更大变化所抵消，从而导致男性OSA的发病率更高。
Obstructive sleep apnea (OSA) has a marked male predominance. To determine whether there are differences in the mechanical properties of the pharynx of men and women that may contribute to the gender difference In disease incidence, we measured pharyngeal cross-sectional area during quiet breathing in 77 normal men and 98 normal women using the acoustic pulse technique. Standard pulmonary function tests were also performed. Pharyngeal mechanics were studied in 23 men and 34 women by measuring the change in pharyngeal area during a slow vital capacity maneuver. Gender was found to be the most important independent factor contributing to pharyngeal size. The men had a significantly larger pharynx than the women (3.63 +/- 0.10 versus 3.20 +/- 0.09 cm2, mean +/- SEM; p < 0.01). Pharyngeal mechanics were also different between men and women. The men had a larger change in pharyngeal area with changing lung volume than the women (0.60 +/- 0.14 versus 0.12 +/- 0.12 cm2, mean +/- SEM; p < 0.02). This difference persisted even after normalizing the data for pharyngeal size. We found that there are gender-related differences in the size and mechanical properties of the pharynx and speculate that the larger pharynx of men may be more than offset by greater changes in pharyngeal size with changing lung volume, contributing to the greater incidence of OSA in men.