Thioredoxin reductase activity is decreased by selenium deficiency
Thioredoxin reductase activity is decreased by selenium deficiency
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DOI：
10.1006/bbrc.1997.6618
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发表时间：
1997-05-19
影响因子：
3.1
通讯作者：
Burk, RF
中科院分区：
文献类型：
--
作者：
Hill, KE;McCollum, GW;Burk, RF
动物硫氧还蛋白还原酶是一种硒蛋白。在这项研究中，硫氧还蛋白还原酶的活动在肝脏，肾脏和大脑中进行了比较，在大鼠喂养硒缺乏和控制饮食14周后断奶。硒缺乏导致硫氧还蛋白还原酶活性从对照组下降到肝脏的4.5%和肾脏的11%。然而，脑硫氧还蛋白还原酶活性并没有受到这种严重程度的硒缺乏的影响。金以其对硒酶的典型作用方式抑制肝脏中硫氧还蛋白还原酶的活性，补充硒-硒缺乏大鼠肝脏中硫氧还蛋白还原酶活性的增加比谷胱甘肽过氧化物酶活性的增加快，但比硒蛋白P活性的增加慢。这些结果表明，肝脏和肾脏中硫氧还蛋白还原酶活性对硒营养状况敏感，而脑中硫氧还蛋白还原酶活性对硒营养状况敏感。还原酶活性较不敏感。(C)北京：科学出版社.
Animal thioredoxin reductase is a selenoprotein. In this study, thioredoxin reductase activities in liver, kidney, and brain have been compared in rats fed selenium-deficient and control diets for 14 weeks following weaning. Selenium deficiency caused a decrease in thioredoxin reductase activity from control to 4.5% in liver and 11% in kidney. However, brain thioredoxin reductase activity was not affected by selenium deficiency of this severity. Gold inhibited thioredoxin reductase activity in the liver in a manner typical of its effect on selenoenzymes, Repletion of selenium-deficient rats with injections of selenium caused thioredoxin reductase activity to increase more rapidly in the liver than glutathione peroxidase activity but more slowly than selenoprotein P. These results indicate that thioredoxin reductase activity in liver and kidney is sensitive to selenium nutritional status but that brain thioredoxin reductase activity is less sensitive. (C) 1997 Academic Press.