Risk factor for steatorrhea in pediatric chronic pancreatitis patients.
Risk factor for steatorrhea in pediatric chronic pancreatitis patients.
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小儿慢性胰腺炎患者脂肪泻的危险因素
DOI：
10.1186/s12876-018-0902-z
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发表时间：
2018
影响因子：
2.4
通讯作者：
Hu Liang-Hao
中科院分区：
文献类型：
--
作者：
Hao Lu;Wang Teng;He Lin;Bi Ya-Wei;Zhang Di;Zeng Xiang-Peng;Xin Lei;Pan Jun;Wang Dan;Ji Jun-Tao;Du Ting-Ting;Lin Jin-Huan;Wang Li-Sheng;Zou Wen-Bin;Chen Hui;Xie Ting;Guo Hong-Lei;Li Bai-Rong;Liao Zhuan;Xu Zheng-Lei;Li Zhao-Shen;Hu Liang-Hao
研究背景慢性胰腺炎（chronic pancreatitis，CP）多见于小儿，尤其是合并脂肪性胰腺炎的患儿.本研究旨在确定儿童CP中脂肪酸的发生率和危险因素。据我们所知，有没有儿科研究，以记录在CP的steatorabolism的自然史。MethodsCP患者入院到我们的中心，从2000年1月至2013年12月入组。根据CP发病时的年龄，将患者分为儿童组（< 18岁）和成人组。计算两组的累积脂肪代谢率。两组的危险因素进行了识别，分别。ResultsThe中位随访时间为整个队列为7.6年。在总计2153例患者中，13.5%为儿科患者。儿科CP的平均发病年龄和诊断年龄分别为11.622岁和19.727岁。在儿童组的46例患者（46/291，15.8%）和成人组的447例患者（447/1862，24.0%）中检测到脂肪酸。年龄在发病的CP（风险比[HR]，1.121），糖尿病（DM，HR，51.140），和重症急性胰腺炎（SAP，HR，13.946）被确定为危险因素的steatorphism在儿科group.ConclusionsAge在发病的CP，DM和SAP被确定为危险因素的发展，steatorphism在儿科CP患者。建议对高危人群进行密切随访。他们可能会受益于充分的胰腺外分泌替代治疗。
BackgroundPediatric patients always suffer from chronic pancreatitis (CP), especially those with steatorrhea. This study aimed to identify the incidence of and risk factors for steatorrhea in pediatric CP. To our best knowledge, there is no pediatric study to document the natural history of steatorrhea in CP.MethodsCP patients admitted to our center from January 2000 to December 2013 were enrolled. Patients were assigned to the pediatric (< 18 years old) and adult group according to their age at onset of CP. Cumulative rates of steatorrhea in both groups were calculated. Risk factors for both groups were identified, respectively.ResultsThe median follow-up duration for the whole cohort was 7.6 years. In a total of 2153 patients, 13.5% of them were pediatrics. The mean age at the onset and the diagnosis of CP in pediatrics were 11.622 and 19.727, respectively. Steatorrhea was detected in 46 patients (46/291, 15.8%) in the pediatric group and in 447 patients (447/1862, 24.0%) in the adult group. Age at the onset of CP (hazard ratio [HR], 1.121), diabetes mellitus (DM, HR, 51.140), and severe acute pancreatitis (SAP, HR, 13.946) was identified risk factor for steatorrhea in the pediatric group.ConclusionsAge at the onset of CP, DM and SAP were identified risk factors for the development of steatorrhea in pediatric CP patients. The high-risk populations were suggested to be followed up closely. They may benefit from a full adequate pancreatic exocrine replacement therapy.