Persistence of Vancomycin Resistance in Multiple Clones of Enterococcus faecium Isolated from Danish Broilers 15 Years after the Ban of Avoparcin
Persistence of Vancomycin Resistance in Multiple Clones of Enterococcus faecium Isolated from Danish Broilers 15 Years after the Ban of Avoparcin
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DOI：
10.1128/aac.05072-14
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发表时间：
2015-05-01
影响因子：
4.9
通讯作者：
Guardabassi, Luca
中科院分区：
文献类型：
--
作者：
Bortolaia, Valeria;Mander, Manuela;Guardabassi, Luca
在禁止阿伏帕辛15年后，在100只丹麦肉鸡群中调查了万古霉素耐药屎肠球菌（VREF）的发生和多样性。VREF发生在47个鸡群中，粪便浓度低，只能通过选择性富集检测。万古霉素耐药可能与多株大肠杆菌中存在可转移的不可分型质粒谱系有关。粪菌克隆共选择的序列类型842四环素的使用，只有部分解释了万古霉素耐药性的持久性，在可检测的质粒共耐药和毒素抗毒素系统的情况下。
The occurrence and diversity of vancomycin-resistant Enterococcus faecium (VREF) were investigated in 100 Danish broiler flocks 15 years after the avoparcin ban. VREF occurred in 47 flocks at low fecal concentrations detectable only by selective enrichment. Vancomycin resistance was prevalently associated with a transferable nontypeable plasmid lineage occurring in multiple E. faecium clones. Coselection of sequence type 842 by tetracycline use only partly explained the persistence of vancomycin resistance in the absence of detectable plasmid coresistance and toxin-antitoxin systems.