The emerging role of computerized tomography in assessing cancer cachexia.
The emerging role of computerized tomography in assessing cancer cachexia.
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DOI：
10.1097/spc.0b013e328331124a
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发表时间：
2009-12-01
影响因子：
2.1
通讯作者：
Baracos, Vickie E
中科院分区：
文献类型：
--
作者：
Prado, Carla M M;Birdsell, Laura A;Baracos, Vickie E
综述目的：本文综述了计算机断层扫描(CT)的潜在机会性应用，以加强我们对癌症恶病质中异常的身体成分，特别是瘦和脂肪组织的改变的了解。因此，一个专门区分这些组织的身体成分工具在评估这种综合征时是必不可少的。癌症患者常规通过高分辨率成像(如CT)进行评估，以便进行诊断和随访。最近利用CT图像进行身体成分分析的工作揭示了癌症恶病质的自然历史，包括骨骼肌、脂肪组织、器官和肿瘤肿块的进行性改变。基于CT的骨骼肌量化可以识别出骨骼肌减少的个体，以及骨骼肌减少与功能状态、化疗毒性、肿瘤进展时间和死亡率之间的联系。总结：从癌症患者的健康记录中常规获得的CT图像可以用于量化特定的瘦肉和脂肪组织，在基于人群的研究中解释身体成分，并在临床和治疗决策环境中评估个别患者。
PURPOSE OF REVIEW: The present review represents an overview of the potential opportunistic use of computerized tomography (CT) to enhance our understanding of abnormal body composition, specifically lean and adipose tissue changes in cancer cachexia.RECENT FINDINGS: One of the characteristics of cancer cachexia is the depletion of muscle with or without adipose tissue loss. Therefore, a body composition tool that specifically distinguishes between these tissues is essential in assessing this syndrome. Cancer patients are routinely evaluated by high resolution imaging such as CT for the purpose of diagnosis and follow-up. Recent work exploiting CT images for body composition analysis has revealed the natural history of cancer cachexia, including progressive alterations in skeletal muscle, adipose tissue, organs, and tumor mass. CT-based quantification of skeletal muscle has permitted identification of individuals with sarcopenia, and links between sarcopenia and functional status, chemotherapy toxicity, time to tumor progression, and mortality.SUMMARY: CT images routinely acquired from health records of cancer patients can be used to quantify specific lean and adipose tissues, to interpret body composition in population-based studies, and to evaluate individual patients in a clinical and therapeutic decision-making setting.