Secretin and the Zollinger--Ellison syndrome: reliability of secretin tests and pathogenetic role of secretin.
Secretin and the Zollinger--Ellison syndrome: reliability of secretin tests and pathogenetic role of secretin.
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促胰液素和佐林格-埃里森综合征：促胰液素测试的可靠性和促胰液素的致病作用。
DOI：
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发表时间：
1978
影响因子：
1.9
通讯作者：
O. B. D. Muckadell
中科院分区：
文献类型：
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作者：
Stage Jg;F. Stadil;J. F. Rehfeld;Jan Fahrenkrug;O. B. D. Muckadell
由于促胰液素试验已用于建立Zollinger-Ellison（Z-E）诊断，因此比较了静脉输注（1 CU/kg/h）或注射（1 CU/kg）促胰液素对经证实的Z-E诊断（n = 25）或十二指肠溃疡病（n = 19）的高分泌者血清胃泌素浓度的影响。两组血清胃泌素浓度均升高。仅注射后Z-E患者的胃泌素反应显著更高，但数值重叠，一些Z-E患者没有反应。因此，与普通溃疡病相比，分泌素在Z-E患者中没有相反的作用，并且“阳性”试验既不是Z-E诊断的充分标准，也不是必要标准。将血清胃泌素分离成各种成分并不能提高诊断价值。术前和术后研究表明，全胃切除术不影响胃泌素对促胰液素的反应（n = 5）或血清胃泌素水平（n = 8）。据推测，分泌素发挥作用的P…
Because secretin tests have been used to establish the Zollinger-Ellison (Z-E) diagnosis, the effects of i.v. infusion (1 CU/kg/h) or injection (1 CU/kg) of secretin on serum concentrations of gastrin in hypersecretors with a verified Z-E diagnosis (n = 25) or duodenal ulcer disease (n = 19) were compared. Serum concentrations of gastrin rose in both groups. The gastrin response was significantly higher in Z-E patients after the injection only, but values were overlapping and some Z-E patients did not respond. Thus secretin does not have inverse action in Z-E patients compared with ordinary ulcer disease, and a ‘positive’ test is neither a sufficient nor a necessary criterion for the Z-E diagnosis. The diagnostic value was not augmented by fractionation of serum gastrin into the various components. Pre- and post-operative studies showed that total gastrectomy did not influence either the gastrin response to secretin (n = 5) or the serum gastrin level (n = 8). It has been speculated that secretin plays a p...