Alternative RNA splicing-generated cardiac troponin T isoform switching: A non-heart-restricted genetic programming synchronized in developing cardiac and skeletal muscles
Alternative RNA splicing-generated cardiac troponin T isoform switching: A non-heart-restricted genetic programming synchronized in developing cardiac and skeletal muscles
复制标题
DOI：
10.1006/bbrc.1996.1267
复制
发表时间：
1996-08-23
影响因子：
3.1
通讯作者：
Jin, JP
中科院分区：
文献类型：
--
作者：
Jin, JP
在鸟类和哺乳动物心脏发育过程中发现了另一种RNA剪接产生的心肌肌钙蛋白T（cTnT）亚型转换。本研究表明，在围产期心脏发育过程中，小鼠cTnT亚型转换比大鼠早10天左右。小鼠cTnT亚型转换也类似于转录调节的肌钙蛋白I（TnI）亚型转换的10天前，在小鼠和大鼠心脏发育过程中显示出相似的时间转换。此外，在大鼠和鸡心脏发育过程中观察到同步cTnT和TnI开关。更有趣的是，cTnT在小鼠和大鼠新生儿骨骼肌中的表达显示出与相应物种的新生儿心脏中的cTnT亚型转换同步的亚型转换模式。结果表明，在发育过程中，替代RNA剪接产生的cTnT异构体转换（a）不是对围产期心肌功能变化的直接反应，（B）不是心脏中的限制性调节，而是由一种种物种特异性编程控制的，该编程在发育中的心肌和骨骼肌中同步进行。(C)出版社：Academic Press，Inc.
An alternative RNA splicing-generated cardiac troponin T (cTnT) isoform switching has been found during both avian and mammalian heart development. The present study demonstrates that the mouse cTnT isoform switching is similar to 10 days earlier than that in rat during perinatal heart development. The mouse cTnT isoform switching is also similar to 10 days earlier than the transcriptionally regulated troponin I (TnI) isoform switching, a transition that showed similar timing during mouse and rat heart development. In addition, synchronized cTnT and TnI switches are observed during both rat and chicken heart development. More interestingly, the expression of cTnT in both mouse and rat neonatal skeletal muscles showed an isoform transition pattern synchronized with the cTnT isoform switching in the neonatal heart of the corresponding species. The results suggest that the alternative RNA splicing-generated cTnT isoform switching during development is (a) not a direct response to the functional changes in perinatal myocardium and (b) not a restricted regulation in the heart, bur is controlled by a species-specific programming that is synchronized in developing cardiac and skeletal muscles. (C) 1996 Academic Press, Inc.