Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes
Insulin secretion capacity in the development from normal glucose tolerance to type 2 diabetes
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DOI：
10.1016/j.diabres.2003.11.024
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发表时间：
2004-12-01
影响因子：
5.1
通讯作者：
Seino, Y
中科院分区：
文献类型：
--
作者：
Fukushima, M;Suzuki, H;Seino, Y
我们研究了日本人胰岛素分泌和胰岛素抵抗对葡萄糖耐受不良的影响。以OGTT结果为基础，采用胰岛素分泌和胰岛素敏感性等指标。糖耐量异常从NGT到IGT再到DM的发展过程中，胰岛素分泌能力下降明显。与其他类型的糖尿病相比，胰岛素生成指数下降明显。NGT受试者开始出现胰岛素分泌轻微受损。从NGT经单纯IGT进展为单纯攻毒后高血糖，被认为主要是由于早期胰岛素分泌恶化。结论：在日本，胰岛素分泌能力下降在NGT向2型糖尿病发展中起一定作用。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
We have examined the contribution of insulin secretion and insulin resistance to glucose intolerance in Japanese. Some indices of insulin secretion and insulin sensitivity based on the results of OGTT were used. The decline of insulin secretion capacity was significant throughout the development of glucose intolerance from NGT via IGT to DM. Decreased insulinogenic indices were conspicuous when it is compared with other types of diabetes. Slight impairment of insulin secretion has begun in subjects with NGT. The progression from NGT via isolated IGT to isolated post-challenge hyperglycemia was considered mostly due to the deterioration of early-phase insulin secretion. It is summazied that decreased insulin secretion capacity takes a definite role in the development from NGT to type 2 diabetes in Japan. (C) 2004 Elsevier Ireland Ltd. All rights reserved.