Prognostic implication of cellular DNA content in acute lymphoblastic leukemia.
Prognostic implication of cellular DNA content in acute lymphoblastic leukemia.
复制标题
急性淋巴细胞白血病细胞 DNA 含量的预后意义。
DOI：
10.1097/00043426-198821000-00013
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
M. Maeda
中科院分区：
文献类型：
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作者：
M. Tsurusawa;N. Katano;S. Kawai;T. Fujimoto;M. Maeda
为评价流式细胞术检测急性淋巴细胞白血病（ALL）细胞DNA含量的预后价值，我们研究了74例ALL患儿治疗前骨髓原始细胞DNA含量的分布。根据他们的白色血细胞计数和诊断时的年龄，他们被分为标准和高风险组，并随访长达44个月。在26名儿童中检测到异常DNA干细胞，并且所有儿童都具有超二倍体DNA含量（DNA指数大于1.0）。在两个风险组中，超二倍体DNA干细胞的缓解持续时间明显长于二倍体DNA干细胞。在标准风险组中，DNA含量和常见ALL抗原是重要的预后因素，尤其是前者。在高危组中，DNA含量也显示出与临床结局的独立显著相关性。
To assess the prognostic value of the cellular DNA content measured by flow cytometry in acute lymphoblastic leukemia (ALL), we studied the pretreatment distribution of the DNA content in marrow blasts from 74 children with this disease. They were divided into standard- and high-risk groups according to their white blood cell counts and age at the time of diagnosis and were followed for up to 44 months. Abnormal DNA stemlines were detected in 26 children, and all of them had a hyperdiploid DNA content (DNA index of greater than 1.0). The duration of remission was significantly longer in those with hyperdiploid DNA stemlines than in those with diploid DNA stemlines in both risk groups. In the standard-risk group, the DNA content and common ALL antigen were significant prognostic factors, especially the former. In the high-risk group, the DNA content also showed an independent significant correlation with the clinical outcome.