Patched1 regulates Hedgehog signaling at the primary cilium
Patched1 regulates Hedgehog signaling at the primary cilium
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DOI：
10.1126/science.1139740
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发表时间：
2007-07-20
期刊：
影响因子：
56.9
通讯作者：
Scott, Matthew P.
中科院分区：
文献类型：
--
作者：
Rohatgi, Rajat;Milenkovic, Ljiljana;Scott, Matthew P.
在哺乳动物中，初级纤毛对Hedgehog （Hh）信号的转导至关重要。我们研究了初级纤毛在调节Sonic Hedgehog （Shh）受体Patched1 （Ptc1）中的作用。Ptc1定位于纤毛，并通过阻止其在纤毛内的积累来抑制Smoothened （Smo）。当Shh与Ptc1结合时，Ptc1离开纤毛，导致Smo的积累和信号的激活。因此，初级纤毛感知Shh并转导在发育、癌变和干细胞功能中发挥关键作用的信号。
Primary cilia are essential for transduction of the Hedgehog (Hh) signal in mammals. We investigated the role of primary cilia in regulation of Patched1 (Ptc1), the receptor for Sonic Hedgehog (Shh). Ptc1 localized to cilia and inhibited Smoothened (Smo) by preventing its accumulation within cilia. When Shh bound to Ptc1, Ptc1 left the cilia, leading to accumulation of Smo and activation of signaling. Thus, primary cilia sense Shh and transduce signals that play critical roles in development, carcinogenesis, and stem cell function.