Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa.
Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa.
复制标题
视网膜炎与视网膜炎色素性的眼睛中的视网膜血管衰减与视觉功能的关联。
DOI：
10.2147/opth.s66326
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Yoshimura N
中科院分区：
文献类型：
--
作者：
Nakagawa S;Oishi A;Ogino K;Makiyama Y;Kurimoto M;Yoshimura N
目的探讨视网膜色素变性（RP）患者视力改变与视网膜血管衰减的关系。回顾性、纵向、观察性队列研究。我们分析了在我们诊所随访≥3年的45例受试者的45只眼。使用基于计算机的交互式血管分析程序，确定视网膜中央动脉当量（CRAE）和视网膜中央静脉当量（CRVE）。年龄和性别匹配的正常对照组从我们的眼底照片库中选择。分析视力、视野面积（Goldmann视野检查，V4 e白色测试灯）、平均偏差（Humphrey视野检查，中心10-2程序）和中心黄斑厚度（光学相干断层扫描）与CRAE和CRVE的相关性。RP眼CRAE和CRVE分别为94.9±13.5 μm和155.6±20.0 μm，对照眼分别为138.1±14.7 μm和215.0±20.4 μm，两组比较差异有统计学意义（P<0.001）。随访3年后，视野面积与CRAE（r=0.584，P<0.01）和CRVE（r=0.500，P=0.008）均相关。平均偏差与CRAE之间也存在显著相关性（r=0.298，P=0.047）。在RP眼中，基线时较窄的血管口径与3年随访期间视力的较大下降相关（CRAE：r=-0.344，P=0.021; CRVE：r=-0.314，P=0.035）。视网膜血管管径与RP患者的某些视功能相关。
To investigate the association between visual changes and retinal vessel attenuation in patients with retinitis pigmentosa (RP). A retrospective, longitudinal, observational cohort study. We analyzed 45 eyes from 45 subjects who were followed-up for ≥3 years at our clinic. Using the computer-based Interactive Vessel Analysis program, central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) were determined. Age- and sex-matched controls from normal subjects were selected from our archived fundus photograph library. Visual acuity, visual field area (Goldmann perimetry, V4e white test light), mean deviation (Humphrey perimetry, central 10-2 program), and central macular thickness (optical coherence tomography) were analyzed for correlations with CRAE and CRVE. Both CRAE and CRVE were significantly decreased in RP eyes (94.9±13.5 μm and 155.6±20.0 μm, respectively) compared with control eyes (138.1±14.7 μm and 215.0±20.4 μm, respectively, both P<0.001). After 3 years of follow-up, visual field area was associated with both CRAE (r=0.584, P<0.01) and CRVE (r=0.500, P=0.008). A significant association was also observed between mean deviation and CRAE (r=0.298, P=0.047). In eyes with RP, a narrower vessel caliber at baseline was associated with a larger decline in visual acuity over the 3-year follow-up interval (CRAE: r=−0.344, P=0.021; CRVE: r=−0.314, P=0.035). Retinal vessel caliber is associated with some visual functions in patients with RP.