LONG-TERM REMISSION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION WITH AS-NEEDED ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY.
LONG-TERM REMISSION OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION WITH AS-NEEDED ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY.
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DOI：
10.1097/iae.0000000000001572
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发表时间：
2018-03
期刊：
影响因子：
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通讯作者：
Freeman WR
中科院分区：
文献类型：
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作者：
Muftuoglu IK;Alam M;You QS;Gaber R;Ramkumar HL;Mendoza N;Meshi A;Freeman WR
目的 确定新生血管性年龄相关性黄斑变性 (AMD) 长期缓解 (LTR) 患者的表现特征，长期缓解 (LTR) 定义为在必要的抗血管内皮生长因子治疗期间，在频域光学相干断层扫描 (SD-OCT) 上没有视网膜内 (IRF)、视网膜下液 (SRF) 或出血，并且在荧光素血管造影 (FA) 上没有渗漏超过 6 个月。将 LTR 患者的表现特征与对照组（包括 28 名年龄、性别和种族匹配的未实现 LTR 患者的 32 只眼睛）进行比较。 LTR 组中 74% 的患者患有 1 型脉络膜新生血管膜 (CNV)，18.5% 患有视网膜血管瘤增生 (RAP)。对照组中，28只眼患有1型CNV（87.5%），并且没有患者患有RAP；总体而言，两组之间的病变类型存在显着差异（p=0.036）。就诊时患有 LTR 的眼睛的中心凹下脉络膜厚度明显较薄（147 与 178 μm，p=0.04）。与对照组（28.1% IRF 和 34.4% SRF，p=0.03）相比，缓解组就诊时 IRF 较多，SRF 较少（59.3% IRF 和 11.1% SRF）。在接受 AMD 按需治疗的患者中，出现 RAP、脉络膜厚度较薄、IRF 较多和 SRF 较少与 LTR 相关。
To determine the presenting characteristics of neovascular age-related macular degeneration (AMD) patients with long-term remission (LTR), which was defined as the absence of intraretinal (IRF), subretinal fluid (SRF), or hemorrhage on spectral domain optical coherence tomography (SD-OCT) and absence of leakage on fluorescein angiography (FA) for longer than 6 months while on as needed anti-vascular endothelial growth factor treatment. The presenting characteristics of patients with LTR was compared to a control group including 32 eyes of 28 age-, gender- and ethnicity-matched patients who did not achieve LTR. Seventy-four percent of patients in LTR group had type 1 choroidal neovascular membrane (CNV) and 18.5% had retinal angiomatous proliferation (RAP). In the control group, 28 eyes had type 1 CNV (87.5%), and none of the patients had RAP; overall, there was a significant difference in lesion types between the 2 groups (p=0.036). Eyes with LTR at presentation had significantly thinner subfoveal choroidal thickness (147 vs. 178 μm, p=0.04). There was more IRF and less SRF at the presentation in the remission group (59.3% IRF and 11.1% SRF) compared to the control group (28.1% IRF and 34.4% SRF, p=0.03). The presence of RAP, thinner choroidal thickness, more IRF, and less SRF at presentation were associated with LTR in patients receiving as-needed treatment for AMD.