NUCLEAR-CHANGES IN APOPTOSIS
NUCLEAR-CHANGES IN APOPTOSIS
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DOI：
10.1016/0955-0674(95)80088-3
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发表时间：
1995-06-01
影响因子：
7.5
通讯作者：
EARNSHAW, WC
中科院分区：
文献类型：
--
作者：
EARNSHAW, WC
Ced-3/白细胞介素-1 β转换酶家族的特异性蛋白酶触发驱动凋亡事件的多酶级联反应。新开发的无细胞系统的研究已经开始确定这些和其他蛋白酶在细胞凋亡中的底物。对完整细胞的研究表明，基因组切割成结构域大小的片段先于第二种核酸酶的激活，第二种核酸酶将DNA片段化为核小体大小的片段。
Specific proteinases of the Ced-3/interleukin-1 beta converting enzyme family trigger a multi-enzyme cascade that drives apoptotic events. Studies with newly developed cell-free systems have begun to identify the substrates of these and other proteinases in apoptosis. Studies with intact cells have revealed that cleavage of the genome into domain-sized fragments precedes the activation of a second nuclease that fragments the DNA into nucleosome-sized pieces.