In silico modelling of mass transfer & absorption in the human gut.
In silico modelling of mass transfer & absorption in the human gut.
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DOI：
10.1016/j.jfoodeng.2015.10.019
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发表时间：
2016-05
影响因子：
5.5
通讯作者：
Bakalis S
中科院分区：
文献类型：
--
作者：
Moxon TE;Gouseti O;Bakalis S
用电子计算机模型研究了淀粉和葡萄糖在小肠中的消化和吸收。我们要解决的主要问题是胃排空时间和管腔粘度对葡萄糖吸收率的相对影响。结果表明，各因素对葡萄糖的吸收率均有显著影响。对于低腔粘度(例如，低于0.1 mPaS)，吸收速率由胃排空时间控制。对于高于0.1ppa的粘度，粘度增加10倍可导致所吸收的葡萄糖减少4倍。我们的模型，以及用来开发它的简化，表明对于高粘度的管腔阶段，胃排空率不是营养可利用性的控制机制。开发一个机制模型可以帮助阐明控制消化过程的限速步骤。胃和小肠被模拟为理想的反应器。葡萄糖的吸收被模拟为管腔内粘度的函数。增加粘度会降低葡萄糖的吸入量。胃排空率是影响营养物质吸收的重要因素。
An in silico model has been developed to investigate the digestion and absorption of starch and glucose in the small intestine. The main question we are aiming to address is the relative effect of gastric empting time and luminal viscosity on the rate of glucose absorption. The results indicate that all factors have a significant effect on the amount of glucose absorbed. For low luminal viscosities (e.g. lower than 0.1 Pas) the rate of absorption is controlled by the gastric emptying time. For viscosities higher than 0.1 Pas a 10 fold increase in viscosity can result in a 4 fold decrease of glucose absorbed. Our model, with the simplifications used to develop it, indicate that for high viscosity luminal phases, gastric emptying rate is not the controlling mechanism for nutrient availability. Developing a mechanistic model could help elucidate the rate limiting steps that control the digestion process. The stomach and small intestine were modelled as ideal reactors. Absorption of glucose was modelled as a function of viscosity within the lumen. Increasing the viscosity reduced the amount of glucose absorbed. The gastric emptying rate is an important factor in the absorption of nutrients.