A click approach to unprotected glycodendrimers
A click approach to unprotected glycodendrimers
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DOI：
10.1021/ma052448w
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发表时间：
2006-03-21
期刊：
影响因子：
5.5
通讯作者：
Riguera, R
中科院分区：
文献类型：
--
作者：
Fernandez-Megia, E;Correa, J;Riguera, R
点击化学与超滤相结合，使得无保护的炔衍生的碳水化合物与三代叠氮基-末端化的没食子酸-三甘醇树枝状聚合物在水性条件下快速、有效和可靠地多价连接。报道的程序允许原子经济的掺入LIP到27个未保护的岩藻糖，甘露糖和乳糖残基，在可重复的高产率（LIP到92%），只需要催化量的铜。在所有情况下，通过H-1 NMR和MALDI-TOF MS明确确定了缀合过程的完成。
Click chemistry in combination with ultrafiltration has allowed the quick, efficient, and reliable multivalent con Ligation of unprotected alkyne-derived carbohydrates to three generations of azido-terininated gallic acid-triethylene glycol dendrimers Under aqueous conditions. The reported procedure allows the atom economical incorporation Of LIP to 27 Unprotected fucose, mannose, and lactose residues, in reproducible high yields (LIP to 92%), requiring only catalytic amounts of Cu. The completion of the conjugation process was clearly established in all cases by both H-1 NMR and MALDI-TOF MS.