Nuclear, but not cytoplasmic, localization of survivin as a negative prognostic factor for survival in upper urinary tract urothelial carcinoma
Nuclear, but not cytoplasmic, localization of survivin as a negative prognostic factor for survival in upper urinary tract urothelial carcinoma
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DOI：
10.1007/s00428-012-1343-7
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发表时间：
2013-01-01
期刊：
影响因子：
3.5
通讯作者：
Tsukamoto, Taiji
中科院分区：
文献类型：
--
作者：
Kitamura, Hiroshi;Torigoe, Toshihiko;Tsukamoto, Taiji
Survivin是凋亡抑制蛋白基因家族的一员，具有抑制细胞凋亡和促进有丝分裂的作用。我们确定了生存素的细胞核或细胞质定位是否可以预测上尿路尿路上皮癌（UUTUC）患者的生存率。我们对125例接受根治性肾输尿管切除术的UUTUC患者的存档标本进行了Survivin免疫组化染色。细胞核和细胞质中存活素的染色进行评分，并与临床病理特征和癌症特异性生存（CSS）进行比较。Survivin的核表达与肿瘤分级显著相关（p
Survivin, a member of the inhibitor of apoptosis protein gene family, inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localization of survivin could predict survival of patients with upper urinary tract urothelial carcinoma (UUTUC). Immunohistochemical staining for survivin was carried out on archival specimens from 125 consecutive patients with UUTUC who underwent radical nephroureterectomy. Nuclear and cytoplasmic staining of survivin was scored and compared with clinicopathologic features and cancer-specific survival (CSS). Nuclear expression of survivin was significantly correlated with tumor grade (p