Relation between serum bilirubin levels ≥450 μmol/L and bilirubin encephalopathy; a Danish population-based study
Relation between serum bilirubin levels ≥450 μmol/L and bilirubin encephalopathy; a Danish population-based study
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DOI：
10.1111/j.1651-2227.2011.02565.x
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发表时间：
2012-04-01
期刊：
影响因子：
3.8
通讯作者：
Vandborg, Pernille K.
中科院分区：
文献类型：
--
作者：
Ebbesen, Finn;Bjerre, Jesper V.;Vandborg, Pernille K.
目的：描述血清总胆红素（TsB）>= 450 μ mol/L与急性中、急性晚期和慢性胆红素脑病（bilirubinencephalopathy.）之间的关系。材料和方法：根据国家实验室信息系统，收集2000年至2007年间出生于丹麦的胎龄>= 35周的所有TsB >= 450 μ mol/L的婴儿。诊断为胆红素脑病的婴儿在丹麦国家登记处的Patients.Results：502766胎龄≥ 35周的婴儿被确定。224例患者的TsB >= 450 μ mol/L，相当于发病率为45/100 000/年，并且在此期间有所增加。TsB峰值为450-499、500-599和600-1000 μ mol/L的婴儿发病率分别为29.6/10万、12.7/10万和2.2/10万。3例为急性晚期胆红素脑病并有严重后遗症，2例为急性中期脑病，发育正常。峰值TsB>= 544 μ mol/L。当TsB峰值为600-1000 μ mol/L时，急性晚期和慢性胆红素脑病的危险性为27%（95% CI 6; 61），其发生率为0.6/10万（95% CI 0.1; 1.7）。结论：TsB ≥ 450 μ mol/L的婴儿发生率为45/10万/年。TsB >= 600 μ mol/L的婴儿发生急性晚期和慢性胆红素脑病的风险很大，这些疾病的发生率为0.6/100 000。
Aim: Describe the relation between levels of total serum bilirubin (TsB) >= 450 mu mol/L and acute intermediate, acute advanced and chronic bilirubin encephalopathy.Material and methods: All infants born at gestational age >= 35 weeks in Denmark between 2000 and 2007 with a TsB >= 450 mu mol/L according to the national laboratory information system. Infants diagnosed with bilirubin encephalopathy were found in the Danish National Registry of Patients.Results: 502 766 infants at gestational age >= 35 weeks were identified. Two hundred twenty-four developed a TsB >= 450 mu mol/L, equivalent to an incidence of 45/100 000/year, and it increased during the period. Incidence of infants with peak TsB of 450-499, 500-599 and 600-1000 mu mol/L were 29.6, 12.7 and 2.2 per 100 000, respectively. Three infants had acute advanced bilirubin encephalopathy and got severe sequelae, whereas the two infants with acute intermediate encephalopathy developed normally. Their peak TsB was >= 544 mu mol/L. Having a peak TsB 600-1000 mu mol/L, the risk of acute advanced and chronic bilirubin encephalopathy was 27% (95% CI 6; 61), and the incidence of these conditions was 0.6 (95% CI 0.1; 1.7) per 100 000.Conclusion: The incidence of infants with TsB >= 450 mu mol/L was 45/100 000/year. Infants with a TsB >= 600 mu mol/L had a substantial risk of developing acute advanced and chronic bilirubin encephalopathy, and the incidence of these conditions was 0.6 per 100 000.