Four New Antibacterial Constituents from Senecio cannabifolius.
Four New Antibacterial Constituents from Senecio cannabifolius.
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DOI：
10.1080/13880200600798502
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发表时间：
2006-01
影响因子：
3.8
通讯作者：
Bin Wu;W. Lin;Huiyuan Gao;Lu Zheng;Li Jun Wu;Chul-Sa Kim
中科院分区：
文献类型：
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作者：
Bin Wu;W. Lin;Huiyuan Gao;Lu Zheng;Li Jun Wu;Chul-Sa Kim
摘要 从千里光(Senecio cannabifolius) 正丁醇提取物中分离出四种新的化学成分：大麻素B、大麻素C、大麻素B 和大麻内酯A。较少的。 （菊科）。分离化合物的结构确定为 3-[3,4-二羟基-5-(羟甲基)四氢呋喃-2-基]-5-羟基呋喃-2(5H)-一 (1)、8,10-二羟基-7-(羟甲基)-4-甲基-1、6-二氧杂螺[4.5] dec-3-en-2-一 (2)、 6-(1,2-二羟基-乙基)-3-[3-(3,4-二羟基-5-羟甲基-四氢-呋喃-2-基)-5-羟基-吡咯-2-亚基]-4-羟基-四氢-吡喃-2-酮(3)和5-羟基-3-{[5-(羟甲基)呋喃-2-基]亚甲基}苯并呋喃-2(3H)-酮（4）分别通过光谱（UV、IR、NMR 和 MS）方法。所有化合物均表现出对金黄色葡萄球菌的抗菌活性。和枯草芽孢杆菌。但不是大肠杆菌..
Abstract Four novel chemical constituents, cannabiside B, cannabiside C, cannabiloid B, and cannabilactone A, have been isolated from the n.-butanol extract of the herb of Senecio cannabifolius. Less. (Compositae). The structures of the isolated compounds were established as 3-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-hydroxyfuran-2(5H)-one (1), 8,10-dihydroxy-7-(hydroxymethyl)-4-methyl-1, 6-dioxaspiro [4.5] dec-3-en-2-one (2), 6-(1,2-dihydroxy-ethyl)-3-[3-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-hydroxy-pyrrol-2-ylidene]-4-hydroxy-tetrahydro-pyran-2-one (3), and 5-hydroxy-3-{[5-(hydroxylmethyl)furan-2-yl] methylene} benzofuran-2(3H)-one (4), respectively, by spectroscopic (UV, IR, NMR, and MS) methods. All the compounds showed antibacterial activities against Staphylococcus aureus. and Bacillus subtilis. but not Escherichia coli..