Evidence of increased chloroquine sensitivity in Thai isolates of Plasmodium falciparum.
Evidence of increased chloroquine sensitivity in Thai isolates of Plasmodium falciparum.
复制标题
泰国恶性疟原虫分离株对氯喹敏感性增加的证据。
DOI：
10.1016/0035-9203(88)90255-6
复制
发表时间：
1988
影响因子：
2.2
通讯作者：
G. Beale
中科院分区：
文献类型：
--
作者：
S. Thaithong;L. Suebsaeng;W. Rooney;G. Beale
2用两种方法测定了1978-1986年收集的恶性疟原虫泰国分离株对氯喹的敏感性：（i）在药物存在下培养分离株72小时，和（ii）WHO标准体外微量试验。在此期间，有迹象表明药物敏感性逐渐增加，与此同时，泰国停止使用氯喹治疗恶性疟疾。
2 Sensitivity of Thai isolates ofPlasmodium falciparumto chloroquine collected over the years 1978–1986 was measured by two methods: (i) by growth of previously cultured isolates for 72 h in presence of drug, and (ii) by the WHO standardin vitromicrotest. During this period there were signs of a gradual increase in drug sensitivity, coinciding with the withdrawal of chloroquine for treatment of falciparum malaria in Thailand.