Cross-frequency phase-phase coupling between θ and γ oscillations in the hippocampus.
Cross-frequency phase-phase coupling between θ and γ oscillations in the hippocampus.
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DOI：
10.1523/jneurosci.4122-11.2012
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发表时间：
2012-01-11
期刊：
影响因子：
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通讯作者：
Buzsáki G
中科院分区：
文献类型：
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作者：
Belluscio MA;Mizuseki K;Schmidt R;Kempter R;Buzsáki G
神经元振荡允许对神经元峰电位进行时间分割。相互依赖的振荡器能够整合多层信息。我们在大鼠迷宫探索和快速眼动睡眠期间检测了海马CA1区θ和γ振荡器的相位 - 相位耦合。海马θ波是不对称的，与用于相位估计的传统方法相比，通过识别基于波形的峰电位相位，动物空间位置的估计得到了改善。利用基于波形的θ相位，识别出3个不同的γ频段：慢γS（30 - 50赫兹）、中频γM（50 - 90赫兹）和快γF（90 - 150赫兹或ε频段）。每个子频段的振幅都受到θ相位的调制。此外，我们发现θ与γS和γM振荡器之间存在可靠的相位 - 相位耦合，但与γF振荡器之间没有。我们认为，跨频率相位耦合能够支持在结构内和跨结构对神经元峰电位进行多时间尺度的控制。
Neuronal oscillations allow for temporal segmentation of neuronal spikes. Interdependent oscillators can integrate multiple layers of information. We examined phase-phase coupling of theta and gamma oscillators in the CA1 region of rat hippocampus during maze exploration and REM sleep. Hippocampal theta waves were asymmetric, and estimation of the spatial position of the animal was improved by identifying the waveform-based phase of spiking, compared to traditional methods used for phase estimation. Using the waveform-based theta phase, 3 distinct gamma bands were identified: slow gammaS (30-50 Hz), mid-frequency gammaM (50-90 Hz) and fast gammaF (90-150 Hz or epsilon band). The amplitude of each sub-band was modulated by the theta phase. In addition, we found reliable phase-phase coupling between theta and both gammaS and gammaM but not gammaF oscillators. We suggest that cross-frequency phase coupling can support multiple time-scale control of neuronal spikes within and across structures.